Substantial research has implicated the hypothalamic‐pituitary‐adrenal (HPA) and
hypothalamic‐pituitary‐gonadal (HPG) axes independently in adolescent mental health …

Objectives To study associations candidate genes for age at menarche with a risk of
endometrial hyperplasia (EH). Methods 52 candidate loci for age at menarche were …

Hypospadias is a common congenital condition in boys in which the urethra opens on the
underside of the penis. We performed a genome-wide association study on 1,006 surgery …

Context: Delayed puberty (DP) is a common issue and, in the absence of an underlying
condition, is typically self limited. Alhough DP seems to be heritable, no specific genetic …

Background & Aims Genetic factors are believed to affect risk for irritable bowel syndrome
(IBS), but there have been no sufficiently powered and adequately sized studies. To identify …

Research question Are the candidate genes for age at menarche associated with a risk of
endometriosis? Design Fifty-two candidate single nucleotide polymorphisms (SNP) for age …

There are dramatic individual differences among adolescents in how and when they
become sexually active adults, and early sexual activity is frequently cited as a cause of …

Over the last decades, the onset of puberty in girls has occurred earlier, but the tempo of
pubertal progression has been relatively slower, resulting in a younger age at puberty onset …

Little is known about genes regulating male puberty. Further, while many identified pubertal
timing variants associate with age at menarche, a late manifestation of puberty, and body …

MicroRNAs (miRNAs) modulate physiological responses by repressing the expression of
gene networks. We found that global deletion of microRNA-7 (miR-7), the most enriched …