Development of the mammalian kidney
AP McMahon - Current topics in developmental biology, 2016 - Elsevier
The basic unit of kidney function is the nephron. In the mouse, around 14,000 nephrons form
in a 10-day period extending into early neonatal life, while the human fetus forms the adult …
in a 10-day period extending into early neonatal life, while the human fetus forms the adult …
Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney development
F Costantini, R Kopan - Developmental cell, 2010 - cell.com
The two major components of the kidney, the collecting system and the nephron, have
different developmental histories. The collecting system arises by the reiterated branching of …
different developmental histories. The collecting system arises by the reiterated branching of …
Mammalian kidney development: principles, progress, and projections
MH Little, AP McMahon - Cold Spring Harbor …, 2012 - cshperspectives.cshlp.org
The mammalian kidney is a vital organ with considerable cellular complexity and functional
diversity. Kidney development is notable for requiring distinct but coincident tubulogenic …
diversity. Kidney development is notable for requiring distinct but coincident tubulogenic …
Conserved and divergent features of human and mouse kidney organogenesis
NO Lindström, JA McMahon, J Guo, T Tran… - Journal of the …, 2018 - journals.lww.com
Human kidney function is underpinned by approximately 1,000,000 nephrons, although the
number varies substantially, and low nephron number is linked to disease. Human kidney …
number varies substantially, and low nephron number is linked to disease. Human kidney …
Progressive recruitment of mesenchymal progenitors reveals a time-dependent process of cell fate acquisition in mouse and human nephrogenesis
Mammalian nephrons arise from a limited nephron progenitor pool through a reiterative
inductive process extending over days (mouse) or weeks (human) of kidney development …
inductive process extending over days (mouse) or weeks (human) of kidney development …
Conserved and divergent features of mesenchymal progenitor cell types within the cortical nephrogenic niche of the human and mouse kidney
Cellular interactions among nephron, interstitial, and collecting duct progenitors drive
mammalian kidney development. In mice, Six2+ nephron progenitor cells (NPCs) and …
mammalian kidney development. In mice, Six2+ nephron progenitor cells (NPCs) and …
Identification of a multipotent self-renewing stromal progenitor population during mammalian kidney organogenesis
A Kobayashi, JW Mugford, AM Krautzberger, N Naiman… - Stem cell reports, 2014 - cell.com
The mammalian kidney is a complex organ consisting of multiple cell types. We previously
showed that the Six2-expressing cap mesenchyme is a multipotent self-renewing progenitor …
showed that the Six2-expressing cap mesenchyme is a multipotent self-renewing progenitor …
Global quantification of tissue dynamics in the developing mouse kidney
Although kidneys of equal size can vary 10-fold in nephron number at birth, discovering
what regulates such variation has been hampered by a lack of quantitative parameters …
what regulates such variation has been hampered by a lack of quantitative parameters …
Single-cell transcriptomics reveals gene expression dynamics of human fetal kidney development
The current understanding of mammalian kidney development is largely based on mouse
models. Recent landmark studies revealed pervasive differences in renal embryogenesis …
models. Recent landmark studies revealed pervasive differences in renal embryogenesis …
Single cell analysis of the developing mouse kidney provides deeper insight into marker gene expression and ligand-receptor crosstalk
Recent advances in the generation of kidney organoids and the culture of primary nephron
progenitors from mouse and human have been based on knowledge of the molecular basis …
progenitors from mouse and human have been based on knowledge of the molecular basis …