Schizophrenia is a complex, chronic mental health disorder whose heterogeneous genetic
and neurobiological background influences early brain development, and whose precise …

Severe psychiatric disorders such as schizophrenia are related to cognitive and negative
symptoms, which often are resistant to current treatment approaches. The glutamatergic …

Alzheimer's disease (AD) is a severe neurodegenerative disorder still in search of effective
methods of diagnosis. Altered levels of the NMDA receptor co-agonist, d-serine, have been …

Recent evidence suggests that Alzheimer's disease (AD) and depression share common
mechanisms of pathogenesis. In particular, deregulation of glutamate-mediated excitatory …

D-Serine is a potent co-agonist at the NMDA glutamate receptor and has been the object of
many preclinical studies to ascertain the nature of its metabolism, its regional and cellular …

Background: Schizophrenia is associated with increased physical morbidity and early
mortality, suggesting that the aging process may be accelerated in schizophrenia. However …

In 1976, I (JTC) finished my psychiatric residency, received my first National Institutes of
Health grant, opened my laboratory, and took responsibility for the Schizophrenia Outpatient …

The development of new techniques to study glial cells has revealed that they are active
participants in the development of functional neuronal circuits. Calcium imaging studies …

Abstract d-Serine acts as a co-agonist of N-methyl-d-aspartate receptors (NMDAR) which
appear overactivated in AD, while d-aspartate is a modulatory molecule acting on NMDAR …

The importance of chiral amino acids (AAs) in living organisms has been widely recognized
since the discovery of endogenous D-AAs as potential biomarkers in several metabolic …