[HTML][HTML] SARS-CoV-2 variant biology: immune escape, transmission and fitness

AM Carabelli, TP Peacock, LG Thorne… - Nature Reviews …, 2023 - nature.com
In late 2020, after circulating for almost a year in the human population, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) exhibited a major step change in its …

Animal models for COVID-19: advances, gaps and perspectives

C Fan, Y Wu, X Rui, Y Yang, C Ling, S Liu… - Signal transduction and …, 2022 - nature.com
Abstract COVID-19, caused by SARS-CoV-2, is the most consequential pandemic of this
century. Since the outbreak in late 2019, animal models have been playing crucial roles in …

Mosaic RBD nanoparticles protect against challenge by diverse sarbecoviruses in animal models

AA Cohen, N van Doremalen, AJ Greaney, H Andersen… - Science, 2022 - science.org
To combat future severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants
and spillovers of SARS-like betacoronaviruses (sarbecoviruses) threatening global health …

Animal models in SARS-CoV-2 research

H Chu, JFW Chan, KY Yuen - Nature methods, 2022 - nature.com
Animal models in SARS-CoV-2 research | Nature Methods Skip to main content Thank you for
visiting nature.com. You are using a browser version with limited support for CSS. To obtain the …

The T-cell-directed vaccine BNT162b4 encoding conserved non-spike antigens protects animals from severe SARS-CoV-2 infection

CM Arieta, YJ Xie, DA Rothenberg, H Diao, D Harjanto… - Cell, 2023 - cell.com
T cell responses play an important role in protection against beta-coronavirus infections,
including SARS-CoV-2, where they associate with decreased COVID-19 disease severity …

[HTML][HTML] Combination therapy with nirmatrelvir and molnupiravir improves the survival of SARS-CoV-2 infected mice

JH Jeong, S Chokkakula, SC Min, BK Kim, WS Choi… - Antiviral research, 2022 - Elsevier
As the SARS-CoV-2 pandemic remains uncontrolled owing to the continuous emergence of
variants of concern, there is an immediate need to implement the most effective antiviral …

An engineered ACE2 decoy neutralizes the SARS-CoV-2 Omicron variant and confers protection against infection in vivo

N Ikemura, S Taminishi, T Inaba, T Arimori… - Science translational …, 2022 - science.org
The Omicron (B. 1.1. 529) SARS-CoV-2 variant contains an unusually high number of
mutations in the spike protein, raising concerns of escape from vaccines, convalescent …

In vitro and in vivo differences in neurovirulence between D614G, Delta And Omicron BA. 1 SARS-CoV-2 variants

L Bauer, M Rissmann, FFW Benavides… - Acta neuropathologica …, 2022 - Springer
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with
various neurological complications. Although the mechanism is not fully understood, several …

Renin-angiotensin system and sex differences in COVID-19: a critical assessment

MC Chappell - Circulation Research, 2023 - Am Heart Assoc
The current epidemic of corona virus disease (COVID-19) has resulted in an immense
health burden that became the third leading cause of death and potentially contributed to a …

Targeting neutrophils extracellular traps (NETs) reduces multiple organ injury in a COVID-19 mouse model

FP Veras, GF Gomes, BMS Silva, DB Caetité… - Respiratory …, 2023 - Springer
Background COVID-19 is characterized by severe acute lung injury, which is associated with
neutrophil infiltration and the release of neutrophil extracellular traps (NETs). COVID-19 …