MA Liu - Immunological reviews, 2011 - Wiley Online Library
This review provides a detailed look at the attributes and immunologic mechanisms of plasmid DNA vaccines and their utility as laboratory tools as well as potential human …
Following their discovery in the early 1970s, classical human leukocyte antigen (HLA) loci have been the prototypical candidates for genetic susceptibility to infectious disease …
Abstract Development and Phase 3 testing of the most advanced malaria vaccine, RTS, S/AS01, indicates that malaria vaccine R&D is moving into a new phase. Field trials of …
Malaria parasite infection is initiated by the mosquito-transmitted sporozoite stage, a highly motile invasive cell that targets hepatocytes in the liver for infection. A promising approach to …
Malaria is one of the most frequently occurring infectious diseases worldwide, with almost 1 million deaths and an estimated 243 million clinical cases annually. Several candidate …
GA O'Hara, CJA Duncan, KJ Ewer… - Journal of Infectious …, 2012 - academic.oup.com
Background. Vaccine development in human Plasmodium falciparum malaria has been hampered by the exceptionally high levels of CD8+ T cells required for efficacy. Use of …
Summary Background RTS, S/AS02A is a pre-erythrocytic stage malaria vaccine that provides partial protection against infection in malaria-naive adult volunteers and …
Malaria is a leading cause of mortality and morbidity globally, and effective vaccines are urgently needed. Malaria vaccine approaches can be broadly grouped as pre‐erythrocytic …
In the twentieth century vaccine development has moved from the use of attenuated or killed micro‐organisms to protein sub‐unit vaccines, with vaccine immunogenicity assessed by …