Therapeutic strategies for COVID-19: progress and lessons learned
G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …
Broadly neutralizing antibodies to SARS-CoV-2 and other human coronaviruses
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a recently emerged
pathogenic human coronavirus that belongs to the sarbecovirus lineage of the genus …
pathogenic human coronavirus that belongs to the sarbecovirus lineage of the genus …
Molecular characteristics, immune evasion, and impact of SARS-CoV-2 variants
The persistent COVID-19 pandemic since 2020 has brought an enormous public health
burden to the global society and is accompanied by various evolution of the virus genome …
burden to the global society and is accompanied by various evolution of the virus genome …
Close relatives of MERS-CoV in bats use ACE2 as their functional receptors
Q Xiong, L Cao, C Ma, MA Tortorici, C Liu, J Si, P Liu… - Nature, 2022 - nature.com
Middle East respiratory syndrome coronavirus (MERS-CoV) and several bat coronaviruses
use dipeptidyl peptidase-4 (DPP4) as an entry receptor,,–. However, the receptor for …
use dipeptidyl peptidase-4 (DPP4) as an entry receptor,,–. However, the receptor for …
Structures of Omicron spike complexes and implications for neutralizing antibody development
H Guo, Y Gao, T Li, T Li, Y Lu, L Zheng, Y Liu, T Yang… - Cell reports, 2022 - cell.com
The emergence of the SARS-CoV-2 Omicron variant is dominant in many countries
worldwide. The high number of spike mutations is responsible for the broad immune evasion …
worldwide. The high number of spike mutations is responsible for the broad immune evasion …
Net-shaped DNA nanostructures designed for rapid/sensitive detection and potential inhibition of the SARS-CoV-2 virus
We present a net-shaped DNA nanostructure (called “DNA Net” herein) design strategy for
selective recognition and high-affinity capture of intact SARS-CoV-2 virions through spatial …
selective recognition and high-affinity capture of intact SARS-CoV-2 virions through spatial …
[HTML][HTML] Advances in the development of therapeutic strategies against COVID-19 and perspectives in the drug design for emerging SARS-CoV-2 variants
J Yin, C Li, C Ye, Z Ruan, Y Liang, Y Li, J Wu… - Computational and …, 2022 - Elsevier
Abstract Since Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) was
identified in late 2019, the coronavirus disease 2019 (COVID-19) pandemic has challenged …
identified in late 2019, the coronavirus disease 2019 (COVID-19) pandemic has challenged …
PCIF1-mediated deposition of 5′-cap N6,2′-O-dimethyladenosine in ACE2 and TMPRSS2 mRNA regulates susceptibility to SARS-CoV-2 infection
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to
be a major health problem worldwide. Due to the fast emergence of SARS-CoV-2 variants …
be a major health problem worldwide. Due to the fast emergence of SARS-CoV-2 variants …
Pan-sarbecovirus prophylaxis with human anti-ACE2 monoclonal antibodies
F Zhang, J Jenkins, RVH de Carvalho… - Nature …, 2023 - nature.com
Human monoclonal antibodies (mAbs) that target the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) spike protein have been isolated from convalescent …
coronavirus 2 (SARS-CoV-2) spike protein have been isolated from convalescent …
Therapeutic antibodies for COVID-19: is a new age of IgM, IgA and bispecific antibodies coming?
Early humoral immune responses to severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) are dominated by IgM and IgA antibodies, which greatly contribute to virus …
(SARS-CoV-2) are dominated by IgM and IgA antibodies, which greatly contribute to virus …