The PI3K/AKT signalling pathway in inflammation, cell death and glial scar formation after traumatic spinal cord injury: Mechanisms and therapeutic opportunities

X He, Y Li, B Deng, A Lin, G Zhang, M Ma… - Cell …, 2022 - Wiley Online Library
Abstract Objects Traumatic spinal cord injury (TSCI) causes neurological dysfunction below
the injured segment of the spinal cord, which significantly impacts the quality of life in …

[HTML][HTML] Different types of cell death and their shift in shaping disease

S Shen, Y Shao, C Li - Cell death discovery, 2023 - nature.com
Cell death is the irreversible stop of life. It is also the basic physiological process of all
organisms which involved in the embryonic development, organ maintenance and …

Characterization of PANoptosis patterns predicts survival and immunotherapy response in gastric cancer

H Pan, J Pan, P Li, J Gao - Clinical Immunology, 2022 - Elsevier
Accumulating evidence suggests that pyroptosis, apoptosis and necroptosis are deeply
involved in cancer immunity. However, the role of PANoptosis in gastric cancer (GC) …

[HTML][HTML] Knowledge mapping of necroptosis from 2012 to 2021: a bibliometric analysis

J Zhang, L Song, J Jia, W Tian, R Lai, Z Zhang… - Frontiers in …, 2022 - frontiersin.org
Background Necroptosis, a recently discovered programmed cell death, has been
pathologically linked to various diseases and is thus a promising target for treating diseases …

Apoptosis, necroptosis, and pyroptosis as alternative cell death pathways induced by chemotherapeutic agents?

A Gielecińska, M Kciuk, EB Yahya, T Ainane… - … et Biophysica Acta (BBA …, 2023 - Elsevier
For decades, common chemotherapeutic drugs have been established to trigger apoptosis,
the preferred immunologically “silent” form of cell death. The primary objective of this review …

[HTML][HTML] Construction of PANoptosis signature: Novel target discovery for prostate cancer immunotherapy

X Yi, J Li, X Zheng, H Xu, D Liao, T Zhang, Q Wei… - … Therapy-Nucleic Acids, 2023 - cell.com
PANoptosis pathway gene sets encompassing pyroptosis, apoptosis, and necroptosis were
identified from the MSigDB database. We analyzed the perturbations and crosstalk in the …

Toxicity of inorganic arsenic to animals and its treatment strategies

Q Su, Y He, H Pan, H Liu, K Mehmood, Z Tang… - … and Physiology Part C …, 2023 - Elsevier
In nature, arsenic is mostly found in the form of inorganic compounds. Inorganic arsenic
compounds have a variety of uses and are currently used in the manufacture of pesticides …

[HTML][HTML] Difenoconazole causes spleen tissue damage and immune dysfunction of carp through oxidative stress and apoptosis

F Liu, X Li, BK Bello, T Zhang, H Yang, K Wang… - Ecotoxicology and …, 2022 - Elsevier
As the use of pesticides increases year after year, so does the level of residual pesticides in
the aquatic environment, posing a serious threat to non-target organisms. Difenoconazole …

From systemic lupus erythematosus to lupus nephritis: The evolving road to targeted therapies

M Xipell, GM Lledó, AC Egan, F Tamirou… - Autoimmunity …, 2023 - Elsevier
Systemic lupus erythematosus is a chronic autoimmune disease characterized by loss of
tolerance against nuclear and cytoplasmic self-antigens, induction of immunity and tissue …

Pyroptosis in cardiovascular diseases: pumping gasdermin on the fire

TO Yarovinsky, M Su, C Chen, Y Xiang, WH Tang… - Seminars in …, 2023 - Elsevier
Pyroptosis is a form of programmed cell death associated with activation of inflammasomes
and inflammatory caspases, proteolytic cleavage of gasdermin proteins (forming pores in the …