Sirtuins (SIRTs) are a family of class III histone deacetylases (HDACs) consisting of seven
members, widely expressed in mammals. SIRTs mainly participate in metabolic …

In the human body, cell division and metabolism are expected to transpire uneventfully for
approximately 25 years. Then, secondary metabolism and cell damage products …

Skin aging mainly occurs due to intrinsic and extrinsic factors. Extrinsic aging is a
consequence of exposure to ultraviolet radiation. Meanwhile, natural products exhibit …

As a lifelong source of neurons, neural stem cells (NSCs) serve multiple crucial functions in
the brain. The senescence of NSCs may be associated with the onset and progression of …

Doxorubicin (DOX) is an anthracycline antibiotic used as an antitumor treatment. However,
its clinical application is limited due to severe side effects such as cardiotoxicity. In recent …

Objective In this article, we review the articles that have reported the interaction between
Klotho and sirtuins. Recent findings Sirtuins are a family of histone deacetylase enzymes …

U2 small nuclear RNA auxiliary factor 1 (U2AF1) is a multifunctional protein that plays a
crucial role in the regulation of RNA splicing during eukaryotic gene expression. U2AF1 …

SIRT1 was discovered in 1979 but growing interest in this protein occurred only 20 years
later when its overexpression was reported to prolong the lifespan of yeast. Since then …

An important mechanism of gene expression regulation is the epigenetic modification of
histones. The cofactors and substrates for these modifications are often intermediary …

Sirtuins (SIRTs) are a family of proteins with enzymatic activity. In particular, they are a family
of class III NAD+-dependent histone deacetylases and ADP-ribosyltransferases. NAD+ …