Abstract Treatment of metastatic cancer is one of the biggest challenges in anticancer
therapy. Curcumin is interesting nature polyphenolic compound with unique biological and …

Breast cancer (BC), the most common malignancy in women, results from significant
alterations in genetic and epigenetic mechanisms that alter multiple signaling pathways in …

The rhizome of turmeric (Curcuma longa L.) has been used as an herbal medicine, coloring
agent, spice, and food additive for thousands of years in different parts of the world …

Cyclic C5-curcuminoid derivatives are synthetic analogues of the natural product curcumin
possessing diverse pharmacological potential. We described earlier that some of the cyclic …

Fractionation motivated by biological activity screening and NMR characteristic signals
analysis led to the isolation of seventeen diarylpentanoids from the whole plant of Daphne …

Breast cancer is the most common cancer of women—it affects more than 2 million women
worldwide. PTP1B phosphatase can be one of the possible targets for new drugs in breast …

Recently, the diarylpentanoid BP-M345 (5) has been identified as a potent in vitro growth
inhibitor of cancer cells, with a GI50 value between 0.17 and 0.45 µM, showing low toxicity in …

Previously, we reported the in vitro growth inhibitory effect of diarylpentanoid BP-M345 on
human cancer cells. Nevertheless, at that time, the cellular mechanism through which BP …

Antimicrobial resistance arises due to several adaptation mechanisms, being the
overexpression of efflux pumps (EPs) one of the most worrisome. In bacteria, EPs can also …

Diarylpentanoids, a class of natural products and their synthetic analogs which are
structurally related to chalcones, have gained increasing attention due to their wide array of …