The historical reliance of biological research on the use of animal models has sometimes
made it challenging to address questions that are specific to the understanding of human …

Parkinson's disease (PD) is the second most prevalent neurological disorder and has been
the focus of intense investigations to understand its etiology and progression, but it still lacks …

Pneumoconiosis refers to a spectrum of pulmonary diseases caused by inhalation of mineral
dust, usually as the result of certain occupations. The main pathological features include …

Prime editing is a versatile and precise genome editing technique that can directly copy
desired genetic modifications into target DNA sites without the need for donor DNA. This …

The recent development of prime editing (PE) genome engineering technologies has the
potential to significantly simplify the generation of human pluripotent stem cell (hPSC)-based …

Human pluripotent stem cells (hPSCs) provide an invaluable tool for modeling diseases and
hold promise for regenerative medicine. For understanding pluripotency and lineage …

Stem cell-derived retinal organoids recapitulate many landmarks of in vivo differentiation but
lack functional maturation of distinct cell types, especially photoreceptors. Using …

Embryonic development is a complex process that is unamenable to direct observation. In
this study, we implanted a window to the mouse uterus to visualize the developing embryo …

Highly potent animal stem cells either self renew or launch complex differentiation programs,
using mechanisms that are only partly understood. Drosophila female germline stem cells …

Mutations and loss of activity in PARKIN, an E3 ubiquitin ligase, play a role in the
pathogenesis of Parkinson's disease (PD). PARKIN regulates many aspects of mitochondrial …