Psychological and biological mechanisms linking trauma with cardiovascular disease risk

JA Sumner, S Cleveland, T Chen, JL Gradus - Translational psychiatry, 2023 - nature.com
Cardiovascular disease (CVD) is the leading cause of death and disability worldwide, and
experiences of psychological trauma have been associated with subsequent CVD onset …

Immune and epigenetic pathways linking childhood adversity and health across the lifespan

MA Chen, AS LeRoy, M Majd, JY Chen… - Frontiers in …, 2021 - frontiersin.org
Childhood adversity is associated with a host of mental and physical health problems across
the lifespan. Individuals who have experienced childhood adversity (eg, child abuse and …

Adverse childhood experiences: A scoping review of measures and methods

C Karatekin, SM Mason, A Riegelman, C Bakker… - Children and youth …, 2022 - Elsevier
Adverse childhood experiences (ACEs) lead to excess morbidity and mortality. However,
this evidence has not resulted in large-scale efforts to prevent ACEs. We conducted a …

[HTML][HTML] Maternal adverse childhood experiences before pregnancy are associated with epigenetic aging changes in their children

JC Nwanaji-Enwerem, L Van Der Laan, K Kogut… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
Emerging research suggests associations of physical and psychosocial stressors with
epigenetic aging. Although this work has included early-life exposures, data on maternal …

Early life stress, frontoamygdala connectivity, and biological aging in adolescence: a longitudinal investigation

JG Miller, TC Ho, KL Humphreys, LS King… - Cerebral …, 2020 - academic.oup.com
Early life stress (ELS) may accelerate frontoamygdala development related to
socioemotional processing, serving as a potential source of resilience. Whether this circuit is …

Shorter telomere length predicts poor antidepressant response and poorer cardiometabolic indices in major depression

R Rampersaud, GWY Wu, VI Reus, J Lin… - Scientific reports, 2023 - nature.com
Telomere length (TL) is a marker of biological aging, and shorter telomeres have been
associated with several medical and psychiatric disorders, including cardiometabolic …

[HTML][HTML] Misshandlungs-und Vernachlässigungserfahrungen in der Kindheit: Ein Risikofaktor für die soziale Teilhabe ehemals außerfamiliär platzierter junger …

M Schmid, JM Fegert, V Clemens… - Kindheit und …, 2022 - econtent.hogrefe.com
Theoretischer Hintergrund: Eine Reihe von Studien zeigen soziale Folgen von
Misshandlung und Vernachlässigung in der Kindheit im weiteren Lebenslauf. Fragestellung …

[HTML][HTML] Adverse and traumatic exposures, posttraumatic stress disorder, telomere length, and hair cortisol–Exploring associations in a high-risk sample of young adult …

D Bürgin, V Clemens, N Varghese, A Eckert… - Brain, Behavior, & …, 2022 - Elsevier
Abstract Background Childhood adversities (CAs), potentially traumatic exposures (PTEs),
and posttraumatic stress disorder (PTSD) are known to increase the risk for poor health …

[HTML][HTML] Investigating the association of prenatal psychological adversities with mother and child telomere length and neurodevelopment

PJW Naudé, DJ Stein, J Lin, HJ Zar - Journal of Affective Disorders, 2023 - Elsevier
Background Exposure to prenatal maternal psychological adversities can negatively affect
the offspring's developing brain. Shortened telomere length (TL) has been implicated as a …

Telomeres and aging: on and off the planet!

CE Mason, MA Sierra, HJ Feng, SM Bailey - Biogerontology, 2024 - Springer
Improving human healthspan in our rapidly aging population has never been more
imperative. Telomeres, protective “caps” at the ends of linear chromosomes, are essential for …