[HTML][HTML] Mechanism and evolution of human ACE2 binding by SARS-CoV-2 spike
AG Wrobel - Current Opinion in Structural Biology, 2023 - Elsevier
Spike glycoprotein of SARS-CoV-2 mediates viral entry into host cells by facilitating virus
attachment and membrane fusion. ACE2 is the main receptor of SARS-CoV-2 and its …
attachment and membrane fusion. ACE2 is the main receptor of SARS-CoV-2 and its …
[HTML][HTML] SARS-CoV-2 Delta and Omicron variants evade population antibody response by mutations in a single spike epitope
P He, B Liu, X Gao, Q Yan, R Pei, J Sun, Q Chen… - Nature …, 2022 - nature.com
Population antibody response is thought to be important in selection of virus variants. We
report that SARS-CoV-2 infection elicits a population immune response that is mediated by a …
report that SARS-CoV-2 infection elicits a population immune response that is mediated by a …
[HTML][HTML] Heme binding to the SARS-CoV-2 spike glycoprotein
SL Freeman, ASF Oliveira, AE Gallio, A Rosa… - Journal of Biological …, 2023 - ASBMB
The target for humoral immunity, SARS-CoV-2 spike glycoprotein, has become the focus of
vaccine research and development. Previous work demonstrated that the N-terminal domain …
vaccine research and development. Previous work demonstrated that the N-terminal domain …
[PDF][PDF] Cryo-EM reveals binding of linoleic acid to SARS-CoV-2 spike glycoprotein, suggesting an antiviral treatment strategy
The COVID-19 pandemic and concomitant lockdowns presented a global health challenge
and triggered unprecedented research efforts to elucidate the molecular mechanisms and …
and triggered unprecedented research efforts to elucidate the molecular mechanisms and …
[HTML][HTML] An unconventional VH1-2 antibody tolerates escape mutations and shows an antigenic hotspot on SARS-CoV-2 spike
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein
continues to evolve antigenically, impacting antibody immunity. D1F6, an affinity-matured …
continues to evolve antigenically, impacting antibody immunity. D1F6, an affinity-matured …
Disulfide stabilization reveals conserved dynamic features between SARS-CoV-1 and SARS-CoV-2 spikes
X Zhang, Z Li, Y Zhang, Y Liu, J Wang… - Life Science …, 2023 - life-science-alliance.org
SARS-CoV-2 spike protein (S) is structurally dynamic and has been observed by cryo-EM to
adopt a variety of prefusion conformations that can be categorized as locked, closed, and …
adopt a variety of prefusion conformations that can be categorized as locked, closed, and …
Enhanced surface accessibility of SARS-CoV-2 Omicron spike protein due to an altered glycosylation profile
SARS-CoV-2 spike (S) proteins undergo extensive glycosylation, aiding in proper folding,
enhancing stability, and evading host immune surveillance. In this study, we used mass …
enhancing stability, and evading host immune surveillance. In this study, we used mass …
[HTML][HTML] Secondary structures of MERS-CoV, SARS-CoV, and SARS-CoV-2 spike proteins revealed by infrared vibrational spectroscopy
All coronaviruses are characterized by spike glycoproteins whose S1 subunits contain the
receptor binding domain (RBD). The RBD anchors the virus to the host cellular membrane to …
receptor binding domain (RBD). The RBD anchors the virus to the host cellular membrane to …
Virion morphology and on-virus spike protein structures of diverse SARS-CoV-2 variants
The evolution of SARS-CoV-2 variants with increased fitness has been accompanied by
structural changes in the spike (S) proteins that are the major target for the adaptive immune …
structural changes in the spike (S) proteins that are the major target for the adaptive immune …
Modulation of SARS-CoV-2 spike binding to ACE2 through conformational selection
The first step of SARS-CoV-2 infection involves the interaction between the trimeric viral
spike protein (𝑆) and the host angiotensin-converting enzyme 2 (𝐴𝐶𝐸2). The receptor …
spike protein (𝑆) and the host angiotensin-converting enzyme 2 (𝐴𝐶𝐸2). The receptor …