[HTML][HTML] Single‐cell RNA sequencing in cancer research

Y Zhang, D Wang, M Peng, L Tang, J Ouyang… - Journal of Experimental …, 2021 - Springer
Single-cell RNA sequencing (scRNA-seq), a technology that analyzes transcriptomes of
complex tissues at single-cell levels, can identify differential gene expression and epigenetic …

Single-cell RNA sequencing in cardiovascular development, disease and medicine

DT Paik, S Cho, L Tian, HY Chang… - Nature Reviews Cardiology, 2020 - nature.com
Advances in single-cell RNA sequencing (scRNA-seq) technologies in the past 10 years
have had a transformative effect on biomedical research, enabling the profiling and analysis …

Single-nucleus cross-tissue molecular reference maps toward understanding disease gene function

G Eraslan, E Drokhlyansky, S Anand, E Fiskin… - Science, 2022 - science.org
Understanding gene function and regulation in homeostasis and disease requires
knowledge of the cellular and tissue contexts in which genes are expressed. Here, we …

[PDF][PDF] High-resolution single-cell atlas reveals diversity and plasticity of tissue-resident neutrophils in non-small cell lung cancer

S Salcher, G Sturm, L Horvath, G Untergasser… - Cancer cell, 2022 - cell.com
Non-small cell lung cancer (NSCLC) is characterized by molecular heterogeneity with
diverse immune cell infiltration patterns, which has been linked to therapy sensitivity and …

Database resources of the national genomics data center, China national center for bioinformation in 2022

Nucleic Acids Research, 2022 - academic.oup.com
Abstract The National Genomics Data Center (NGDC), part of the China National Center for
Bioinformation (CNCB), provides a family of database resources to support global research …

[HTML][HTML] Systematic assessment of tissue dissociation and storage biases in single-cell and single-nucleus RNA-seq workflows

E Denisenko, BB Guo, M Jones, R Hou, L De Kock… - Genome biology, 2020 - Springer
Background Single-cell RNA sequencing has been widely adopted to estimate the cellular
composition of heterogeneous tissues and obtain transcriptional profiles of individual cells …

[PDF][PDF] Spatiotemporal developmental trajectories in the Arabidopsis root revealed using high-throughput single-cell RNA sequencing

T Denyer, X Ma, S Klesen, E Scacchi, K Nieselt… - Developmental cell, 2019 - cell.com
High-throughput single-cell RNA sequencing (scRNA-seq) is becoming a cornerstone of
developmental research, providing unprecedented power in understanding dynamic …

Understanding nanomaterial–liver interactions to facilitate the development of safer nanoapplications

J Li, C Chen, T Xia - Advanced Materials, 2022 - Wiley Online Library
Nanomaterials (NMs) are widely used in commercial and medical products, such as
cosmetics, vaccines, and drug carriers. Exposure to NMs via various routes such as dermal …

[PDF][PDF] Single-cell RNA sequencing of developing maize ears facilitates functional analysis and trait candidate gene discovery

X Xu, M Crow, BR Rice, F Li, B Harris, L Liu… - Developmental Cell, 2021 - cell.com
Crop productivity depends on activity of meristems that produce optimized plant
architectures, including that of the maize ear. A comprehensive understanding of …

[HTML][HTML] Recent developments in application of single-cell RNA sequencing in the tumour immune microenvironment and cancer therapy

PH Li, XY Kong, YZ He, Y Liu, X Peng, ZH Li… - Military Medical …, 2022 - Springer
The advent of single-cell RNA sequencing (scRNA-seq) has provided insight into the tumour
immune microenvironment (TIME). This review focuses on the application of scRNA-seq in …