Cellular heterogeneity within and across tumors has been a major obstacle in
understanding and treating cancer, and the complex heterogeneity is masked if bulk tumor …

Motivation Single-cell RNA sequencing (scRNA-seq) technologies enable the study of
transcriptional heterogeneity at the resolution of individual cells and have an increasing …

Central to the core principle of cell theory, depicting cells' history, state and fate is a
fundamental goal in modern biology. By leveraging clonal analysis and single-cell RNA-seq …

To define cellular mechanisms underlying kidney function and failure, the KPMP analyzes
biopsy tissue in a multicenter research network to build cell-level process maps of the …

Background Considerable evidence suggests that the heterogeneity of ovarian cancer (OC)
is a major cause of treatment failure. Single-cell RNA sequencing (scRNA-seq) is a powerful …

Breakthroughs in the development of high-throughput technologies for profiling
transcriptomes at the single-cell level have helped biologists to understand the …

Kidney macrophages are central in kidney disease pathogenesis and have therapeutic
potential in preventing tissue injury and fibrosis. Recent studies highlighted that kidney …

Noncoding RNAs (ncRNAs) are a large segment of the transcriptome that do not have
apparent protein-coding roles, but they have been verified to play important roles in diverse …

A pressing challenge in single-cell transcriptomics is to benchmark experimental protocols
and computational methods. A solution is to use computational simulators, but existing …

Abstract Characterization of immune responses is currently hampered by the lack of systems
enabling quantitative and dynamic phenotypic characterization of individual cells and, in …