Background The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular'reactive oxygen species'(ROSs) can exhibit a …

Inflammation is considered to play a central role in a diverse range of disease outcomes
associated with exposure to various types of inhalable particulates. The initial mechanisms …

Xanthine oxidase (XO) is a critical source of reactive oxygen species (ROS) in inflammatory
disease. Focus, however, has centered almost exclusively on XO-derived superoxide …

As the red cell emerges from the bone marrow, it loses its nucleus, ribosomes, and
mitochondria and therefore all capacity for protein synthesis. However, because of the high …

One of the unique features of β-cells is their relatively low expression of many antioxidant
enzymes. This could render β-cells susceptible to oxidative damage but may also provide a …

With the appearance of new viruses and infectious diseases (ID) such as COVID-19 in 2019,
as well as the lack of specific pharmacological tools for the management of patients with …

Berberine (BBR) has been shown to improve several metabolic disorders, such as obesity,
type 2 diabetes, and dyslipidemia, by stimulating AMP-activated protein kinase (AMPK) …

Oxidative stress, particularly reactive oxygen species (ROS), are important for innate
immunity against pathogens. ROS directly attack pathogens, regulate and amplify immune …

The lung is a delicate organ with a large surface area that is continuously exposed to the
external environment, and is therefore highly vulnerable to exogenous sources of oxidative …

Parkinson's disease is characterized by the progressive degeneration of dopaminergic
neurons in the substantia nigra. We have previously reported that lipopolysaccharide (LPS) …