Organophosphorus (OP) pesticides and nerve agents still pose a threat to the population.
Treatment of OP poisoning is an ongoing challenge and burden for medical services …

Since the September 11, 2001, terrorist attacks in the United States, the specter of a
chemical threat against civilian populations has renewed research interest in chemical …

Objective Endophenotype studies of obsessive-compulsive disorder (OCD) may uncover
heritable traits that are related to genetic susceptibility to OCD. Deficient response inhibition …

Poisoning by organophosphorus compounds (OP) still is a major therapeutic problem.
Intentional OP pesticide poisoning results in up to 300.000 deaths each year and highly …

Sarin (GB, O-isopropyl methylphosphonofluoridate) is a potent organophosphorus (OP)
nerve agent that inhibits acetylcholinesterase (AChE) irreversibly. The subsequent build-up …

Organophosphate pesticides (OPPs; eg chlorpyrifos, diazinon, paraoxon) are a wide and
heterogeneous group of organophosphorus compounds. Their biological activity of …

A-series agent A-234 belongs to a new generation of nerve agents. The poisoning of a
former Russian spy Sergei Skripal and his daughter in Salisbury, England, in March 2018 …

The standard treatment of intoxication with organophosphorus (OP) compounds includes the
administration of oximes acting as acetylcholinesterase (AChE) reactivating antidotes …

Poisoning and overdose are very important aspects in medicine and toxicology. Chemical
weapons pose a threat to civilians, and emergency medicine principles must be followed …

Over 50 years ago, the toxicity of irreversible organophosphate inhibitors targeting human
acetylcholinesterase (hAChE) was observed to be stereospecific. The therapeutic reversal of …