Apolipoprotein E in Alzheimer's disease trajectories and the next-generation clinical care pathway
S Narasimhan, DM Holtzman, LG Apostolova… - Nature …, 2024 - nature.com
Alzheimer's disease (AD) is a complex, progressive primary neurodegenerative disease.
Since pivotal genetic studies in 1993, the ε4 allele of the apolipoprotein E gene (APOE ε4) …
Since pivotal genetic studies in 1993, the ε4 allele of the apolipoprotein E gene (APOE ε4) …
Pitfalls of predicting age‐related traits by polygenic risk scores
V Escott‐Price, KM Schmidt - Annals of Human Genetics, 2023 - Wiley Online Library
Polygenic risk scores (PRS) are a method increasingly used to capture the combined effect
of genome‐wide significant variants and those which individually do not show genome‐wide …
of genome‐wide significant variants and those which individually do not show genome‐wide …
Peripheral GFAP and NfL as early biomarkers for dementia: longitudinal insights from the UK Biobank
X Wang, Z Shi, Y Qiu, D Sun, H Zhou - BMC medicine, 2024 - Springer
Background Peripheral glial fibrillary acidic protein (GFAP) and neurofilament light chain
(NfL) are sensitive markers of neuroinflammation and neuronal damage. Previous studies …
(NfL) are sensitive markers of neuroinflammation and neuronal damage. Previous studies …
Genetic and multi-omic resources for Alzheimer disease and related dementia from the Knight Alzheimer Disease Research Center
MV Fernandez, M Liu, A Beric, M Johnson, A Cetin… - Scientific data, 2024 - nature.com
Abstract The Knight-Alzheimer Disease Research Center (Knight-ADRC) at Washington
University in St. Louis has pioneered and led worldwide seminal studies that have …
University in St. Louis has pioneered and led worldwide seminal studies that have …
Sport-Specific Abdominal Wall Muscle Differences: A Comparative Study of Soccer and Basketball Players Using Ultrasonography
C Romero-Morales, JH Villafañe, U Torres… - Applied Sciences, 2024 - mdpi.com
Aim: This study aims to compare the thickness of abdominal wall muscles—the external
oblique (EO), internal oblique (IO), transversus abdominis (TrAb), rectus abdominis (RA) …
oblique (EO), internal oblique (IO), transversus abdominis (TrAb), rectus abdominis (RA) …
A genetic and proteomic comparison of key AD biomarkers across tissues
TW Marsh, D Western, J Timsina, P Gorijala… - Alzheimer's & … - Wiley Online Library
INTRODUCTION Plasma has been proposed as an alternative to cerebrospinal fluid (CSF)
for measuring Alzheimer's disease (AD) biomarkers, but no studies have analyzed in detail …
for measuring Alzheimer's disease (AD) biomarkers, but no studies have analyzed in detail …