The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …

The vascular endothelium is an interface between the blood stream and the vessel wall.
Changes in this single cell layer of the artery wall are believed of primary importance in the …

Oxidized low‐density lipoprotein (OxLDL) contributes to the atherosclerotic plaque formation
and progression by several mechanisms, including the induction of endothelial cell …

The binding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike
glycoprotein to its cellular receptor, the angiotensin-converting enzyme 2 (ACE2), causes its …

Intracranial aneurysms (IAs) linger as a potentially devastating clinical problem. Despite
intense investigation, our understanding of the mechanisms leading to aneurysm …

Emerging evidence supports the notion that inflammation fosters the development of
common benign gynecologic disorders, including uterine leiomyoma, endometriosis, and …

Objective To synthesize more conclusive evidence on the anti-inflammatory effects of
angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers …

Diabetes mellitus is a complex and heterogeneous metabolic disorder which is often pre-or
post-existent with complications such as cardiovascular disease, hypertension …

In spite of the huge amount of research recently performed in this area, the pathogenesis of
human hypertension remains elusive. Thus, hypertension has to be defined as “essential” …

SARS-CoV-2 causes COVID-19, which has claimed millions of lives. This virus can infect
various cells and tissues, including the brain, for which numerous neurological symptoms …