Therapeutic potential and mechanisms of mesenchymal stem cell-derived exosomes as bioactive materials in tendon–bone healing

J Zou, W Yang, W Cui, C Li, C Ma, X Ji, J Hong… - Journal of …, 2023 - Springer
Tendon–bone insertion (TBI) injuries, such as anterior cruciate ligament injury and rotator
cuff injury, are the most common soft tissue injuries. In most situations, surgical …

Effects of BMSC-derived EVs on bone metabolism

X Zhou, H Cao, J Guo, Y Yuan, G Ni - Pharmaceutics, 2022 - mdpi.com
Extracellular vesicles (EVs) are small membrane vesicles that can be secreted by most cells.
EVs can be released into the extracellular environment through exocytosis, transporting …

Exosomes derived from kartogenin-preconditioned mesenchymal stem cells promote cartilage formation and collagen maturation for enthesis regeneration in a rat …

J Cai, J Xu, Z Ye, L Wang, T Zheng… - … American Journal of …, 2023 - journals.sagepub.com
Background: Poor tendon-to-bone healing in chronic rotator cuff tears (RCTs) is related to
unsatisfactory outcomes. Exosomes derived from mesenchymal stem cells reportedly …

Recent advances of exosomes in soft tissue injuries in sports medicine: A critical review on biological and biomaterial applications

Y Xue, N Riva, L Zhao, J Shieh, YT Chin, A Gatt… - Journal of Controlled …, 2023 - Elsevier
Sports medicine is generally associated with soft tissue injuries including muscle injuries,
meniscus and ligament injuries, tendon ruptures, tendinopathy, rotator cuff tears, and tendon …

Engineering exosomes for bone defect repair

S Ma, Y Zhang, S Li, A Li, Y Li, D Pei - Frontiers in bioengineering …, 2022 - frontiersin.org
Currently, bone defect repair is still an intractable clinical problem. Numerous treatments
have been performed, but their clinical results are unsatisfactory. As a key element of cell …

Comparative effects of exosomes and ectosomes isolated from adipose-derived mesenchymal stem cells on achilles tendinopathy in a rat model

T Xu, Y Lin, X Yu, G Jiang, J Wang… - … American journal of …, 2022 - journals.sagepub.com
Background: Extracellular vesicles derived from mesenchymal stem cells (MSC-EVs) have
gained momentum as a treatment for tendinopathy. Multiple studies have demonstrated …

Practical considerations for translating mesenchymal stromal cell-derived extracellular vesicles from bench to bed

PPY Lui, YT Leung - Pharmaceutics, 2022 - mdpi.com
Extracellular vesicles (EVs) derived from mesenchymal stromal cells (MSCs) have shown
potential for the treatment of tendon and ligament injuries. This approach can eliminate the …

[HTML][HTML] Stem cell-based therapeutic strategies for rotator cuff tendinopathy

Z Wang, Y Liao, C Wang, C Tang, C Fang, J Luo… - Journal of Orthopaedic …, 2023 - Elsevier
Rotator cuff tendinopathy is a common musculoskeletal disorder that imposes significant
health and economic burden. Stem cell therapy has brought hope for tendon healing in …

Current progress in growth factors and extracellular vesicles in tendon healing

Y Wang, J Li - International Wound Journal, 2023 - Wiley Online Library
Tendon injury healing is a complex process that involves the participation of a significant
number of molecules and cells, including growth factors molecules in a key role. Numerous …

Exosome-mediated repair of spinal cord injury: a promising therapeutic strategy

T Yu, LL Yang, Y Zhou, MF Wu, JH Jiao - Stem Cell Research & Therapy, 2024 - Springer
Spinal cord injury (SCI) is a catastrophic injury to the central nervous system (CNS) that can
lead to sensory and motor dysfunction, which seriously affects patients' quality of life and …