Proteomics analysis of plasma from middle-aged adults identifies protein markers of dementia risk in later life
A diverse set of biological processes have been implicated in the pathophysiology of
Alzheimer's disease (AD) and related dementias. However, there is limited understanding of …
Alzheimer's disease (AD) and related dementias. However, there is limited understanding of …
Omics-based biomarkers discovery for Alzheimer's disease
Q Aerqin, ZT Wang, KM Wu, XY He, Q Dong… - Cellular and Molecular …, 2022 - Springer
Alzheimer's disease (AD) is the most common neurodegenerative disorders presenting with
the pathological hallmarks of amyloid plaques and tau tangles. Over the past few years …
the pathological hallmarks of amyloid plaques and tau tangles. Over the past few years …
Perspectives of ozone induced neuropathology and memory decline in Alzheimer's disease: A systematic review of preclinical evidences
This systematic review aims to discover the plausible mechanism of Ozone in AD, to boost
translational research. The main focus of our review lies in understanding the effects of …
translational research. The main focus of our review lies in understanding the effects of …
Plasma proteomic profiles predict individual future health risk
Developing a single-domain assay to identify individuals at high risk of future events is a
priority for multi-disease and mortality prevention. By training a neural network, we …
priority for multi-disease and mortality prevention. By training a neural network, we …
Immune system-wide Mendelian randomization and triangulation analyses support autoimmunity as a modifiable component in dementia-causing diseases
Immune system and blood–brain barrier dysfunction are implicated in the development of
Alzheimer's and other dementia-causing diseases, but their causal role remains unknown …
Alzheimer's and other dementia-causing diseases, but their causal role remains unknown …
Impact of hypertension prevalence trend on mortality and burdens of dementia and disability in England and Wales to 2060: a simulation modelling study
Background Previous estimates of the impact of public health interventions targeting
hypertension usually focus on one health outcome. This study aims to consider the effects of …
hypertension usually focus on one health outcome. This study aims to consider the effects of …
Identification of circulating proteins associated with general cognitive function among middle-aged and older adults
Identifying circulating proteins associated with cognitive function may point to biomarkers
and molecular process of cognitive impairment. Few studies have investigated the …
and molecular process of cognitive impairment. Few studies have investigated the …
Large-scale circulating proteome association study (CPAS) meta-analysis identifies circulating proteins and pathways predicting incident hip fractures
TR Austin, HA Fink, DI Jalal, AE Törnqvist… - Journal of Bone and …, 2024 - academic.oup.com
Hip fractures are associated with significant disability, high cost, and mortality. However, the
exact biological mechanisms underlying susceptibility to hip fractures remain incompletely …
exact biological mechanisms underlying susceptibility to hip fractures remain incompletely …
Plasma proteins related to inflammatory diet predict future cognitive impairment
MR Duggan, L Butler, Z Peng, GN Daya… - Molecular …, 2023 - nature.com
Dysregulation of the immune system and dietary patterns that increase inflammation can
increase the risk for cognitive decline, but the mechanisms by which inflammatory nutritional …
increase the risk for cognitive decline, but the mechanisms by which inflammatory nutritional …
Roles of Siglecs in neurodegenerative diseases
Microglia are resident myeloid cells in the central nervous system (CNS) with a unique
developmental origin, playing essential roles in developing and maintaining the CNS …
developmental origin, playing essential roles in developing and maintaining the CNS …