The proper functioning of the immune system requires a robust control over a delicate
equilibrium between an ineffective response and immune overactivation. Poor responses to …

Abstract Type I interferon (IFN-I) production is efficiently induced to ensure a potent innate
immune response to viral infection. How this response can be enhanced, however, remains …

The majority of lncRNAs' roles in tumor immunology remain elusive. This project performed
a CRISPR activation screening of 9744 lncRNAs in melanoma cells cocultured with human …

Thousands of unique noncoding RNAs (ncRNAs) exist within the genomes of higher
eukaryotes. Upon virus infection, the host generates interferons (IFNs), which initiate the …

Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has become a global pandemic threatening the …

ABSTRACT REC8 meiotic recombination protein (REC8) is a member of structural
maintenance of chromosome (SMC) protein partners, which play an important role in …

The innate immune system uses pattern recognition receptors to survey the intracellular and
extracellular environment for signs of infection. Viral infection is detected through the …

RNA has been proposed as an important scaffolding factor in the nucleus, aiding protein
complex assembly in the dense intracellular milieu. Architectural contributions of RNA to …

Long noncoding RNAs (lncRNAs) are RNA molecules longer than 200 nucleotides that
regulate gene expression at the transcriptional and post-transcriptional levels. Emerging …

Long noncoding RNAs (lncRNAs) represent a key class of cellular regulators, involved in the
modulation and control of multiple biological processes. Distinct classes of lncRNAs are now …