The risk of infections for multiple sclerosis and neuromyelitis optica spectrum disorder disease-modifying treatments: Eighth European Committee for Treatment and …

C Tur, AL Dubessy, S Otero-Romero… - Multiple Sclerosis …, 2022 - journals.sagepub.com
Over the recent years, the treatment of multiple sclerosis (MS) and neuromyelitis optica
spectrum disorder (NMOSD) has evolved very rapidly and a large number of disease …

Structure-based neutralizing mechanisms for SARS-CoV-2 antibodies

Q Huang, X Han, J Yan - Emerging Microbes & Infections, 2022 - Taylor & Francis
The devastating economic and public health consequences caused by the COVID-19
pandemic have prompted outstanding efforts from the scientific community and …

[HTML][HTML] Structural basis and mode of action for two broadly neutralizing antibodies against SARS-CoV-2 emerging variants of concern

W Li, Y Chen, J Prévost, I Ullah, M Lu, SY Gong… - Cell reports, 2022 - cell.com
Emerging variants of concern for the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) can transmit more efficiently and partially evade protective immune …

[HTML][HTML] Structures of Omicron spike complexes and implications for neutralizing antibody development

H Guo, Y Gao, T Li, T Li, Y Lu, L Zheng, Y Liu, T Yang… - Cell reports, 2022 - cell.com
The emergence of the SARS-CoV-2 Omicron variant is dominant in many countries
worldwide. The high number of spike mutations is responsible for the broad immune evasion …

[HTML][HTML] A large-scale systematic survey reveals recurring molecular features of public antibody responses to SARS-CoV-2

Y Wang, M Yuan, H Lv, J Peng, IA Wilson, NC Wu - Immunity, 2022 - cell.com
Global research to combat the COVID-19 pandemic has led to the isolation and
characterization of thousands of human antibodies to the SARS-CoV-2 spike protein …

[HTML][HTML] A potently neutralizing SARS-CoV-2 antibody inhibits variants of concern by utilizing unique binding residues in a highly conserved epitope

LA VanBlargan, LJ Adams, Z Liu, RE Chen, P Gilchuk… - Immunity, 2021 - cell.com
With the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
variants with increased transmissibility and potential resistance, antibodies and vaccines …

An ACE2-blocking antibody confers broad neutralization and protection against Omicron and other SARS-CoV-2 variants of concern

W Du, DL Hurdiss, D Drabek, AZ Mykytyn… - Science …, 2022 - science.org
The ongoing evolution of SARS-CoV-2 has resulted in the emergence of Omicron, which
displays notable immune escape potential through mutations at key antigenic sites on the …

The Third dose of CoronVac vaccination induces broad and potent adaptive immune responses that recognize SARS-CoV-2 Delta and Omicron variants

Y Chen, L Chen, S Yin, Y Tao, L Zhu… - Emerging microbes & …, 2022 - Taylor & Francis
The waning humoral immunity and emerging contagious severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) variants resulted in the necessity of the booster vaccination of …

[HTML][HTML] Structure-based discovery of dual pathway inhibitors for SARS-CoV-2 entry

H Wang, Q Yang, X Liu, Z Xu, M Shao, D Li… - Nature …, 2023 - nature.com
Abstract Since 2019, SARS-CoV-2 has evolved rapidly and gained resistance to multiple
therapeutics targeting the virus. Development of host-directed antivirals offers broad …

[HTML][HTML] Omicron SARS-CoV-2 variant spike protein shows an increased affinity to the human ACE2 receptor: an in silico analysis

JT Ortega, B Jastrzebska, HR Rangel - Pathogens, 2021 - mdpi.com
The rise of SARS-CoV-2 variants, with changes that could be related to an increased virus
pathogenicity, have received the interest of the scientific and medical community. In this …