Wogonoside is the main flavonoid component derived from the root of Scutellaria
baicalensis Georgi. It is a popular Chinese herbal medicine with the potential to treat …

Retinoic acid (RA) is used to treat leukemia and other cancers through its ability to promote
cancer cell differentiation. Strategies to enhance the anticancer effects of RA could deepen …

Abstract All-trans-retinoic-acid (ATRA)-induced differentiation of human myeloid leukemia
cells is characterized by persistent mitogen-activated protein kinase (MAPK) signaling …

Acute promyelocytic leukemia (APL) is a treatment success story. From a highly deadly
disease, it was turned into a highly curable disease by the introduction of differentiation …

6-Formylindolo (3, 2-b) carbazole (FICZ) is a photoproduct of tryptophan and an
endogenous high affinity ligand for aryl hydrocarbon receptor (AhR). It was previously …

Novel functions of signaling molecules have been revealed in studies of cancer stem cells.
Retinoic acid (RA) is an embryonic morphogen and stem cell regulator that controls the …

Although ATRA represents a successful differentiation therapy for APL, it is largely
ineffective for non-APL AMLs. Hence combination therapies using an agent targeting ATRA …

All-trans retinoic acid (ATRA)-based differentiation therapy has been unsuccessful in
treating t (15; 17) negative acute myeloid leukemia (AML) patients, motivating interest in …

In binary cell-fate decisions, driving one lineage and suppressing the other are conjoined.
We have previously reported that aryl hydrocarbon receptor (AhR) promotes retinoic acid …

Increasing scientific evidence suggests that most diseases including cancer are driven by
oxidative stress and inflammation, attributed to environmental factors such as diet. This book …