The morbidity and mortality of cardiovascular diseases (CVDs) are increasing worldwide
and seriously threaten human life and health. Fibroblast growth factor 21 (FGF21), a …

Berberine (BBR) is an isoquinoline alkaloid belonging to the structural class of
protoberberines. BBR has been used in traditional medicine to treat diseases, such as type …

Piper longum L. is widely cultivated for food, medicine, and other purposes in tropical and
subtropical regions. Sixteen compounds including nine new amide alkaloids were isolated …

Isatin derivatives have been found to possess anti-proliferative effects against different
human cancer cell lines. A series of isatin-Schiff's base and chalcone were synthesized and …

One of the most important mechanism by which bioflavonoids can exert their effects in
cancer treatment, is through their interaction with bio-macromolecules such as DNA. Recent …

A series of 1 H-benzo [f] chromene moieties (4a–z) were synthesised under Ultrasonic
irradiation and confirmed with spectral analyses. Derivative 4i solely possessed an X-ray …

A class of 4H-benzo [h] chromene (4a-h) and 1H-benzo [f] chromene (6a-h) derivatives
linked to carboxamide/carbothioamide at the 3/2-positions were designed and synthesized …

Colorectal cancer (CRC), a tumor of the digestive system, is characterized by high
malignancy and poor prognosis. Currently, targeted therapy of CRC is far away from …

The target compound 3-amino-1-(2, 5-d ichlorophenyl)-8-methoxy-1 H-benzo [f]-chromene-2-
carbonitrile (4) was synthesized via a reaction of 6-methoxynaphthalen-2-ol (1), 2, 5 …

Colorectal cancer oncogenesis is linked to dysbiosis, oxidative stress and overexpression of
CDK2. The 4 H-pyran scaffold is considered an antitumoral, antibacterial and antioxidant …