Plasmodium falciparum malaria still remains a major global public health challenge with
over 220 million new cases and well over 400,000 deaths annually. Most of the deaths occur …

Highlights•Efficacy of RTS, S vaccine in children supports the concept of a malaria
vaccine.•RTS, S efficacy is limited and life-span is short so improvements are …

Introduction: The challenge to eradicate malaria is an enormous task that will not be
achieved by current control measures, thus an efficacious and long-lasting malaria vaccine …

Radiation‐attenuated sporozoites induce sterilizing immunity and remain the'gold
standard'for malaria vaccine development. Despite practical challenges in translating these …

Introduction: Despite recent advances, malaria remains a major health threat both to
populations in endemic areas as well travelers, including military personnel, to these areas …

Background Plasmodium falciparum is the most deadly and leading cause of morbidity and
mortality in Africa. About 90% of all malaria deaths in the world today occur in Sub-Saharan …

In malaria, CD 4 Th1 and T follicular helper (TFH) cells are important for controlling parasite
growth, but Th1 cells also contribute to immunopathology. Moreover, various regulatory CD …

Introduction: An efficacious malaria vaccine is necessary to advance the current control
measures towards malaria elimination. To-date, only RTS, S/AS01, a leading pre …

In humans and murine models of malaria, intradermal immunization (ID-I) with genetically
attenuated sporozoites that arrest in liver induces lower protective immunity than …

Malaria remains a major public health problem worldwide. The immune mechanisms that
mediate protection against malaria are still unclear. Previously, we reported that …