Extracellular protein components of amyloid plaques and their roles in Alzheimer's disease pathology

MM Rahman, C Lendel - Molecular Neurodegeneration, 2021 - Springer
Alzheimer's disease (AD) is pathologically defined by the presence of fibrillar amyloid β (Aβ)
peptide in extracellular senile plaques and tau filaments in intracellular neurofibrillary …

Alzheimer's disease and type 2 diabetes mellitus: A systematic review of proteomic studies

J Diniz Pereira, V Gomes Fraga… - Journal of …, 2021 - Wiley Online Library
Similar to dementia, the risk for developing type 2 diabetes mellitus (T2DM) increases with
age, and T2DM also increases the risk for dementia, particularly Alzheimer's disease (AD) …

Advances in the pathogenesis of Alzheimer's disease: a re-evaluation of amyloid cascade hypothesis

S Dong, Y Duan, Y Hu, Z Zhao - Translational neurodegeneration, 2012 - Springer
Alzheimer's disease (AD) is a common neurodegenerative disease characterized clinically
by progressive deterioration of memory, and pathologically by histopathological changes …

Plasma protein profiling for potential biomarkers in the early diagnosis of Alzheimer's disease

Y Kitamura, R Usami, S Ichihara, H Kida… - Neurological …, 2017 - Taylor & Francis
Objectives: Alzheimer's disease (AD) is the most common cause of dementia in elderly
persons. Since the pathology of AD develops slowly from a preclinical or early phase into a …

Amyloid-forming properties of human apolipoproteins: sequence analyses and structural insights

M Das, O Gursky - Lipids in Protein Misfolding, 2015 - Springer
Apolipoproteins are protein constituents of lipoproteins that transport cholesterol and fat in
circulation and are central to cardiovascular health and disease. Soluble apolipoproteins …

Plasma high‐density lipoprotein cargo is altered in Alzheimer's disease and is associated with regional brain volume

S Pedrini, JD Doecke, E Hone, P Wang… - Journal of …, 2022 - Wiley Online Library
Cholesterol levels have been repeatedly linked to Alzheimer's Disease (AD), suggesting that
high levels could be detrimental, but this effect is likely attributed to Low‐Density Lipoprotein …

Proteomic profiling of plasma and brain tissue from Alzheimer's disease patients reveals candidate network of plasma biomarkers

M Chen, W Xia - Journal of Alzheimer's Disease, 2020 - content.iospress.com
Background: Alzheimer's disease (AD) is the most prevalent form of dementia with two
pathological hallmarks of tau-containing neurofibrillary tangles and amyloid-β protein (Aβ) …

Circadian Regulation of Apolipoproteins in the Brain: Implications in Lipid Metabolism and Disease

CH Lee, CE Murrell, A Chu, X Pan - International Journal of Molecular …, 2023 - mdpi.com
The circadian rhythm is a 24 h internal clock within the body that regulates various factors,
including sleep, body temperature, and hormone secretion. Circadian rhythm disruption is …

[HTML][HTML] The distinct metabolism between large and small HDL indicates unique origins of human apolipoprotein A4

AB Andraski, SA Singh, H Higashi, LH Lee, M Aikawa… - JCI insight, 2023 - ncbi.nlm.nih.gov
Abstract Apolipoprotein A4's (APOA4's) functions on HDL in humans are not well
understood. A unique feature of APOA4 is that it is an intestinal apolipoprotein secreted on …

Plasma protein biomarker model for screening Alzheimer disease using multiple reaction monitoring-mass spectrometry

Y Kim, J Kim, M Son, J Lee, I Yeo, KY Choi, H Kim… - Scientific reports, 2022 - nature.com
Alzheimer disease (AD) is a leading cause of dementia that has gained prominence in our
aging society. Yet, the complexity of diagnosing AD and measuring its invasiveness poses …