Nucleic Acids as Biotools at the Interface between Chemistry and Nanomedicine in the COVID-19 Era

N Borbone, I Piccialli, AP Falanga, V Piccialli… - International Journal of …, 2022 - mdpi.com
The recent development of mRNA vaccines against the SARS-CoV-2 infection has turned
the spotlight on the potential of nucleic acids as innovative prophylactic agents and as …

Telomeres, senescence, and hematopoietic stem cells

S Zimmermann, UM Martens - Cell and tissue research, 2008 - Springer
The replicative lifespan of normal somatic cells is restricted by the erosion of telomeres,
which are protective caps at the ends of linear chromosomes. The loss of telomeres induces …

Characterization and comparison of telomere length, telomerase and reverse transcriptase activity and gene expression in human mesenchymal stem cells and …

BG Jeon, BM Kumar, EJ Kang, SA Ock, SL Lee… - Cell and tissue …, 2011 - Springer
We have characterized and compared the telomere length, telomerase, reverse
transcriptase (RT) activity and expression of genes implicated in cancer and in pluripotency …

Biological differences between neonatal and adult human hematopoietic stem/progenitor cells

H Mayani - Stem cells and development, 2010 - liebertpub.com
From the first studies performed by Broxmeyer and his group, in the late 1980s, evidence
was presented indicating that hematopoietic progenitor cells from human umbilical cord …

Flu RNA vaccine: a game changer?

F Meurens - Vaccines, 2020 - mdpi.com
Influenza virus infection is a major One Health concern worldwide. Indeed,
Orthomyxoviridae and more specifically Alphainfluenzavirus and Betainfluenzavirus are …

Identification of senescence-associated genes in human bone marrow mesenchymal stem cells

E Ryu, S Hong, J Kang, J Woo, J Park, J Lee… - Biochemical and …, 2008 - Elsevier
Human bone marrow mesenchymal stem cells (hBMMSCs) are multipotent stem cells that
can differentiate into several specialized cell types, including bone, cartilage, and fat cells …

Do RNA vaccines obviate the need for genotoxicity studies?

N Cimolai - Mutagenesis, 2020 - academic.oup.com
In the context of preliminary concerns with vaccine vectors, it may be also be constructive to
discuss whether RNA vaccines would have qualities that obviate any apprehension for …

[HTML][HTML] Adenoviral vectors for transient gene expression in human primitive hematopoietic cells: applications and prospects

M Järås, ACM Brun, S Karlsson, X Fan - Experimental hematology, 2007 - Elsevier
The proliferation and differentiation of primitive hematopoietic cells is tightly controlled by a
number of signaling pathways. Transient blockage or enhancement of these signaling …

Modeling the human 8p11-myeloproliferative syndrome in immunodeficient mice

H Ågerstam, M Järås, A Andersson… - Blood, The Journal …, 2010 - ashpublications.org
The 8p11 myeloproliferative syndrome (EMS), also referred to as stem cell
leukemia/lymphoma, is a chronic myeloproliferative disorder that rapidly progresses into …

[HTML][HTML] Expression of P190 and P210 BCR/ABL1 in normal human CD34+ cells induces similar gene expression profiles and results in a STAT5-dependent …

M Järås, P Johnels, H Ågerstam, C Lassen… - Experimental …, 2009 - Elsevier
OBJECTIVE: The P190 and P210 BCR/ABL1 fusion genes are mainly associated with
different types of hematologic malignancies, but it is presently unclear whether they are …