[HTML][HTML] Nanopore sequencing technology, bioinformatics and applications

Y Wang, Y Zhao, A Bollas, Y Wang, KF Au - Nature biotechnology, 2021 - nature.com
Rapid advances in nanopore technologies for sequencing single long DNA and RNA
molecules have led to substantial improvements in accuracy, read length and throughput …

[HTML][HTML] Long walk to genomics: History and current approaches to genome sequencing and assembly

AM Giani, GR Gallo, L Gianfranceschi… - Computational and …, 2020 - Elsevier
Genomes represent the starting point of genetic studies. Since the discovery of DNA
structure, scientists have devoted great efforts to determine their sequence in an exact way …

[HTML][HTML] Trypanosoma cruzi genetic diversity: impact on transmission cycles and Chagas disease

B Zingales, DC Bartholomeu - Memórias do instituto oswaldo cruz, 2022 - SciELO Brasil
Trypanosoma cruzi, the agent of Chagas disease (ChD), exhibits remarkable biological and
genetic diversity, along with eco-epidemiological complexity. In order to facilitate …

[HTML][HTML] Strain-specific genome evolution in Trypanosoma cruzi, the agent of Chagas disease

W Wang, D Peng, RP Baptista, Y Li, JC Kissinger… - PLoS …, 2021 - journals.plos.org
The protozoan Trypanosoma cruzi almost invariably establishes life-long infections in
humans and other mammals, despite the development of potent host immune responses …

Concepts and consequences of a core gut microbiota for animal growth and development

D Perlman, M Martínez-Álvaro, S Moraïs… - Annual Review of …, 2022 - annualreviews.org
Animal microbiomes are occasionally considered as an extension of host anatomy,
physiology, and even their genomic architecture. Their compositions encompass variable …

[HTML][HTML] Trypanosoma Cruzi Genome: Organization, Multi-Gene Families, Transcription, and Biological Implications

A Herreros-Cabello, F Callejas-Hernández, N Gironès… - Genes, 2020 - mdpi.com
Chagas disease caused by the parasite Trypanosoma cruzi affects millions of people.
Although its first genome dates from 2005, its complexity hindered a complete assembly and …

Long-read assembly and comparative evidence-based reanalysis of Cryptosporidium genome sequences reveal expanded transporter repertoire and duplication of …

RP Baptista, Y Li, A Sateriale, MJ Sanders… - Genome …, 2022 - genome.cshlp.org
Cryptosporidiosis is a leading cause of waterborne diarrheal disease globally and an
important contributor to mortality in infants and the immunosuppressed. Despite its …

[HTML][HTML] Assessing Trypanosoma cruzi Parasite Diversity through Comparative Genomics: Implications for Disease Epidemiology and Diagnostics

A Majeau, L Murphy, C Herrera, E Dumonteil - Pathogens, 2021 - mdpi.com
Chagas disease is an important vector-borne neglected tropical disease that causes great
health and economic losses. The etiological agent, Trypanosoma cruzi, is a protozoan …

Application of nanopore sequencing technology in the clinical diagnosis of infectious diseases

LL Zhang, C Zhang, JP Peng - Biomedical and Environmental Sciences, 2022 - Elsevier
Infectious diseases are an enormous public health burden and a growing threat to human
health worldwide. Emerging or classic recurrent pathogens, or pathogens with resistant …

Third-generation sequencing revises the molecular karyotype for Toxoplasma gondii and identifies emerging copy number variants in sexual recombinants

J Xia, A Venkat, RE Bainbridge, ML Reese… - Genome …, 2021 - genome.cshlp.org
Toxoplasma gondii is a useful model for intracellular parasitism given its ease of culture in
the laboratory and genomic resources. However, as for many other eukaryotes, the T. gondii …