Human genetic studies have long been vastly Eurocentric, raising a key question about the
generalizability of these study findings to other populations. Because humans originated in …

Genome-wide association studies (GWAS) on diverse ancestry groups are lacking, resulting
in deficits of genetic discoveries and polygenic scores. We conducted GWAS for 76 …

Both short and long sleep are associated with an adverse lipid profile, likely through different
biological pathways. To elucidate the biology of sleep-associated adverse lipid profile, we …

Using random germline mutagenesis in mice, we identified a viable hypomorphic allele
(boh) of the transcription-factor-encoding gene Ovol2 that resulted in obesity, which initially …

Background The prevalence of obesity and its related chronic diseases have been
increasing especially in Asian countries. Obesity-related genetic variants have been …

Traditional observational studies have reported a positive association between higher body
mass index (BMI) and the risk of colorectal cancer (CRC). However, evidence from other …

Genome-wide association studies (GWASs) have identified thousands of genetic loci
associated with cardiometabolic traits including type 2 diabetes (T2D), lipid levels, body fat …

Motivation As increasing sample sizes from genome-wide association studies (GWASs),
polygenic risk scores (PRSs) have shown great potential in personalized medicine with …

Assortative mating (AM) is a pattern characterized by phenotypic similarities between mating
partners. Detecting the evidence of AM has been challenging due to the lack of large-scale …

Context The associations of obesity and diabetic nephropathy (DN) in type 2 diabetes are
inconsistent in observational studies, and causality remains unclear. Objective To explore …