Simple Summary Scientists use animal models to study the mechanisms of human diseases
and find new drugs to treat them. Chronic Unpredictable Mild Stress is the best animal …

The failure of preclinical research to advance successful candidate medications in
psychiatry has created a paradigmatic crisis in psychiatry. The Research Domain Criteria …

Rationale Low-voltage-activated or T-type Ca 2+ channels play a key role in the generation
of seizures in absence epilepsy. We have described a homozygous, gain of function …

Experiencing chronic stress significantly increases the risk for depression. Depression is a
complex disorder with varied symptoms across patients. However, feeling of sadness and …

Major depressive disorder is a common psychiatric disorder, with∼ 30% of patients suffering
from treatment-resistant depression. Based on preclinical studies on ketamine, α-amino-3 …

Subarachnoid hemorrhage (SAH) is a severe form of stroke that can cause unpredictable
and diffuse cerebral damage, which is difficult to detect until it becomes irreversible …

Laboratory rats have excellent learning abilities and are often used in cognitive
neuroscience research. The majority of rat studies are conducted on males, whereas …

Background Exposing rats to repeated unpredictable stressors is a popular method for
modelling depression. The sucrose preference test is used to assess the validity of this …

Astrocytes are implicated in stress-induced neuroinflammatory responses in depression.
This paper was to explore the molecular mechanism of the E3 ubiquitin ligase NEDD4L …

Abstract Narcolepsy type 1 (NT1) is a neurological disorder caused by disruption of
hypocretin (HCRT; or orexin) neurotransmission leading to fragmented sleep/wake states …