[HTML][HTML] ApoE in Alzheimer's disease: pathophysiology and therapeutic strategies

AC Raulin, SV Doss, ZA Trottier, TC Ikezu, G Bu… - Molecular …, 2022 - Springer
Alzheimer's disease (AD) is the most common cause of dementia worldwide, and its
prevalence is rapidly increasing due to extended lifespans. Among the increasing number of …

[HTML][HTML] Therapeutic approach to Alzheimer's disease: current treatments and new perspectives

T Pardo-Moreno, A González-Acedo… - Pharmaceutics, 2022 - mdpi.com
Alzheimer's disease (AD) is the most common cause of dementia. The pathophysiology of
this disease is characterized by the accumulation of amyloid-β, leading to the formation of …

[HTML][HTML] Crosstalk between gut and brain in Alzheimer's disease: the role of gut microbiota modulation strategies

U Shabbir, MS Arshad, A Sameen, DH Oh - Nutrients, 2021 - mdpi.com
The gut microbiota (GM) represents a diverse and dynamic population of microorganisms
and about 100 trillion symbiotic microbial cells that dwell in the gastrointestinal tract. Studies …

[HTML][HTML] Is melatonin the “next vitamin D”?: a review of emerging science, clinical uses, safety, and dietary supplements

DM Minich, M Henning, C Darley, M Fahoum… - Nutrients, 2022 - mdpi.com
Nutrients | Free Full-Text | Is Melatonin the “Next Vitamin D”?: A Review of
Emerging Science, Clinical Uses, Safety, and Dietary Supplements Next Article in Journal …

[HTML][HTML] Insulin resistance and diabetes mellitus in Alzheimer's disease

J Burillo, P Marqués, B Jiménez, C González-Blanco… - Cells, 2021 - mdpi.com
Type 2 diabetes mellitus is a progressive disease that is characterized by the appearance of
insulin resistance. The term insulin resistance is very wide and could affect different proteins …

Evaluation and targeting of amyloid precursor protein (APP)/amyloid beta (Aβ) axis in amyloidogenic and non-amyloidogenic pathways: A time outside the tunnel

HM Al-Kuraishy, MS Jabir, AI Al-Gareeb… - Ageing Research …, 2023 - Elsevier
In Alzheimer disease (AD), amyloid precursor protein (APP) and production of amyloid beta
(Aβ) which is generated by amyloidogenic pathway is implicated in neurotoxicity and …

[HTML][HTML] Brain washing and neural health: role of age, sleep, and the cerebrospinal fluid melatonin rhythm

RJ Reiter, R Sharma, MS Cucielo, DX Tan… - Cellular and Molecular …, 2023 - Springer
The brain lacks a classic lymphatic drainage system. How it is cleansed of damaged
proteins, cellular debris, and molecular by-products has remained a mystery for decades …

[HTML][HTML] Research evidence of the role of the glymphatic system and its potential pharmacological modulation in neurodegenerative diseases

JP Verghese, A Terry, ER de Natale… - Journal of Clinical …, 2022 - mdpi.com
The glymphatic system is a unique pathway that utilises end-feet Aquaporin 4 (AQP4)
channels within perivascular astrocytes, which is believed to cause cerebrospinal fluid …

Tetrahydroxy stilbene glycoside ameliorates Alzheimer's disease in APP/PS1 mice via glutathione peroxidase related ferroptosis

Y Gao, J Li, Q Wu, S Wang, S Yang, X Li… - International …, 2021 - Elsevier
Amyloid beta peptide (Aβ) has been confirmed to be an essential reason of Alzheimer's
disease (AD) for a long time. Ferroptosis is a newly recognized oxidative cell death …

[HTML][HTML] A growing link between circadian rhythms, type 2 diabetes mellitus and Alzheimer's disease

X Peng, R Fan, L Xie, X Shi, K Dong, S Zhang… - International journal of …, 2022 - mdpi.com
Type 2 diabetes mellitus (T2DM) patients are at a higher risk of developing Alzheimer's
disease (AD). Mounting evidence suggests the emerging important role of circadian rhythms …