Adjuvants are vaccine components that enhance the magnitude, breadth and durability of
the immune response. Following its introduction in the 1920s, alum remained the only …

Adjuvants are indispensable components of vaccines for stimulating optimal immune
responses to non-replicating, inactivated and subunit antigens. Eliciting balanced humoral …

Ongoing severe acute respiratory syndrome coronavirus–2 (SARS-CoV-2) vaccine
development is focused on identifying stable, cost-effective, and accessible candidates for …

Relative to several other toll-like receptor (TLR) agonists, we found polyinosinic:
polycytidylic acid (poly IC) to be the most effective adjuvant for Th1 CD4+ T cell responses to …

Our improved understanding of how innate immune responses can be initiated and how
they can shape adaptive B‐and T‐cell responses is having a significant impact on vaccine …

Many currently used and candidate vaccine adjuvants are particulate in nature, but their
mechanism of action is not well understood. Here, we show that particulate adjuvants …

Although considerable progress has been made in dissecting the signaling pathways
involved in the innate immune response, it is now apparent that this response can no longer …

CD4+ Th1 type immunity is implicated in resistance to global infectious diseases. To
improve the efficacy of T cell immunity induced by human immunodeficiency virus (HIV) …

Maturation of dendritic cells (DC) to competent APC is essential for the generation of
acquired immunity and is a major function of adjuvants. dsRNA, a molecular signature of …

Adjuvant, as an important part of vaccines, can observably enhance the magnitude, breadth
and durability of immune responses. Nanoadjuvants, as novel vaccine adjuvants, have …