Abstract Purpose of Review Genetic variants in GBA1 and LRRK2 genes are the commonest
genetic risk factor for Parkinson disease (PD); however, the preclinical profile of GBA1 and …

Identifying individuals at high risk for developing neurodegenerative disease opens the
possibility of conducting clinical trials that intervene at an earlier stage of neurodegeneration …

Parkinson's disease (PD) is a debilitating neurodegenerative multisystem disorder leading
to motor and non-motor symptoms in millions of individuals. Despite intense research, there …

The objective of this study was to investigate the association between a Parkinson's disease
(PD)-specific polygenic score (PGS) and protective lifestyle factors on age at onset (AAO) in …

Background A mitochondrial polygenic score (MGS) is composed of genes related to
mitochondrial function and found to be associated with Parkinson's disease (PD) risk …

Human mutations in mitochondrial-associated genes are associated with inflammatory
diseases and susceptibility to infection. However, their mechanistic contributions to immune …

Background Coffee drinking has been associated with decreased risk of some autoimmune
diseases as well liver disease and outcomes. Environmental factors, such as coffee …

Background Subjects carrying mutations in the GBA gene, whether in one or two alleles
pose a risk to develop Parkinson's disease (PD). This type of GBA-related PD has usually a …

The objective of our study was to investigate the impact of the mitochondrial polygenic score
(MGS) and lifestyle/environmental data on age at onset in LRRK2 p. Gly2019Ser …

Background Previous studies linked disease-progression variables such as age at onset or
survival to both genetic, and non-genetic factors in Parkinson's disease (PD) patients …