Parkinson's disease (PD) is a neurodegenerative movement disorder which can be either
familial or sporadic. While it is well known that monogenic mutations are not a very common …

Parkinson's disease is a clinically and genetically heterogeneous movement disorder with
highly variable age-at-onset. DNA methylation (DNAm) age is an epigenetic clock that could …

LRRK2 is a kinase involved in different cellular functions, including autophagy,
endolysosomal pathways and vesicle trafficking. Mutations in LRRK2 cause autosomal …

Substantial evidence has shown that the age at onset (AAO) of Parkinson's disease (PD) is a
major determinant of clinical heterogeneity. However, the mechanisms underlying …

La enfermedad de Parkinson y Alzheimer son las enfermedades neurodegenerativas más
frecuentes a nivel mundial. Tienen etiología multifactorial, entre ellas, la genética; y son …

[en] The objective of our study was to investigate the impact of the mitochondrial polygenic
score (MGS) and lifestyle/environmental data on age at onset in LRRK2 p. Gly2019Ser …

Parkinson's disease (PD) is a progressive neurodegenerative disorder. Genetic modifiers,
environmental factors and gene-environment interactions have been found to modify PD risk …

The objective of our study was to investigate the impact of the mitochondrial polygenic score
(MGS) and lifestyle/environmental data on age at onset in LRRK2 p. Gly2019Ser …

Parkinson's and Alzheimer's are the most frequent neurodegenerative diseases worldwide.
They have a multifactorial etiology, including genetics, and are of interest in current scientific …

Parkinson's disease (PD) is a progressive neurodegenerative disorder. Genetic modifiers,
environmental factors and gene-environment interactions have been found to modify PD risk …