Regulation of drug transport proteins—From mechanisms to clinical impact: A white paper on behalf of the international transporter consortium
Membrane transport proteins are involved in the absorption, disposition, efficacy, and/or
toxicity of many drugs. Numerous mechanisms (eg, nuclear receptors, epigenetic gene …
toxicity of many drugs. Numerous mechanisms (eg, nuclear receptors, epigenetic gene …
Endogenous biomarkers for SLC transporter-mediated drug-drug interaction evaluation
Membrane transporters play an important role in the absorption, distribution, metabolism,
and excretion of xenobiotic substrates, as well as endogenous compounds. The evaluation …
and excretion of xenobiotic substrates, as well as endogenous compounds. The evaluation …
Interactions of anti-COVID-19 drug candidates with hepatic transporters may cause liver toxicity and affect pharmacokinetics
Transporters in the human liver play a major role in the clearance of endo-and xenobiotics.
Apical (canalicular) transporters extrude compounds to the bile, while basolateral …
Apical (canalicular) transporters extrude compounds to the bile, while basolateral …
Iruplinalkib (WX‑0593), a novel ALK/ROS1 inhibitor, overcomes crizotinib resistance in preclinical models for non-small cell lung cancer
Y Yang, Q Zheng, X Wang, S Zhao, W Huang… - Investigational New …, 2023 - Springer
Despite remarkable initial responses of anaplastic lymphoma kinase (ALK) inhibitors in ALK-
positive non-small cell lung cancer (NSCLC) patients, cancers eventually develop …
positive non-small cell lung cancer (NSCLC) patients, cancers eventually develop …
Glycyrrhizic acid prevents paclitaxel-induced neuropathy via inhibition of OATP-mediated neuronal uptake
I Klein, J Isensee, MHJ Wiesen, T Imhof… - Cells, 2023 - mdpi.com
Peripheral neuropathy is a common side effect of cancer treatment with paclitaxel. The
mechanisms by which paclitaxel is transported into neurons, which are essential for …
mechanisms by which paclitaxel is transported into neurons, which are essential for …
Regulation of OATP1B1 function by tyrosine kinase–mediated phosphorylation
ER Hayden, M Chen, KZ Pasquariello, AA Gibson… - Clinical Cancer …, 2021 - AACR
Abstract Purpose: OATP1B1 (SLCO1B1) is the most abundant and pharmacologically
relevant uptake transporter in the liver and a key mediator of xenobiotic clearance. However …
relevant uptake transporter in the liver and a key mediator of xenobiotic clearance. However …
Machine learning models identify new inhibitors for human OATP1B1
TR Lane, F Urbina, X Zhang, M Fye… - Molecular …, 2022 - ACS Publications
The uptake transporter OATP1B1 (SLC01B1) is largely localized to the sinusoidal
membrane of hepatocytes and is a known victim of unwanted drug–drug interactions …
membrane of hepatocytes and is a known victim of unwanted drug–drug interactions …
Darolutamide does not interfere with OATP‐mediated uptake of docetaxel
The addition of darolutamide, an androgen receptor signalling inhibitor, to therapy with
docetaxel has recently been approved as a strategy to treat metastatic prostate cancer …
docetaxel has recently been approved as a strategy to treat metastatic prostate cancer …
Mechanisms of pharmacoresistance in hepatocellular carcinoma: New drugs but old problems
Hepatocellular carcinoma (HCC) is a malignancy with poor prognosis when diagnosed at
advanced stages in which curative treatments are no longer applicable. A small group of …
advanced stages in which curative treatments are no longer applicable. A small group of …
Interaction of antifungal drugs with CYP3A-and OATP1B-mediated venetoclax elimination
Venetoclax, a BCL-2 inhibitor used to treat certain hematological cancers, exhibits low oral
bioavailability and high interpatient pharmacokinetic variability. Venetoclax is commonly …
bioavailability and high interpatient pharmacokinetic variability. Venetoclax is commonly …