[HTML][HTML] m6A regulator-based methylation modification patterns characterized by distinct tumor microenvironment immune profiles in colon cancer
W Chong, L Shang, J Liu, Z Fang, F Du, H Wu, Y Liu… - Theranostics, 2021 - ncbi.nlm.nih.gov
Recent studies have highlighted the biological significance of RNA N 6-methyladenosine (m
6 A) modification in tumorigenicity and progression. However, it remains unclear whether m …
6 A) modification in tumorigenicity and progression. However, it remains unclear whether m …
[HTML][HTML] MiRNAs and lncRNAs in the regulation of innate immune signaling
I Gareev, ME Ramirez, E Goncharov, D Ivliev… - Non-coding RNA …, 2023 - Elsevier
The detection and defense against foreign agents and pathogens by the innate immune
system is a crucial mechanism in the body. A comprehensive understanding of the signaling …
system is a crucial mechanism in the body. A comprehensive understanding of the signaling …
Roles of emerging RNA-binding activity of cGAS in innate antiviral response
Y Ma, X Wang, W Luo, J Xiao, X Song, Y Wang… - Frontiers in …, 2021 - frontiersin.org
cGAS, a DNA sensor in mammalian cells, catalyzes the generation of 2'-3'-cyclic AMP-GMP
(cGAMP) once activated by the binding of free DNA. cGAMP can bind to STING, activating …
(cGAMP) once activated by the binding of free DNA. cGAMP can bind to STING, activating …
[HTML][HTML] N6-methyladenosine (m6A) methyltransferase WTAP accelerates the Warburg effect of gastric cancer through regulating HK2 stability
H Yu, K Zhao, H Zeng, Z Li, K Chen, Z Zhang… - Biomedicine & …, 2021 - Elsevier
Abstract N 6-methyladenosine (m 6 A) is one of the most abundant messenger RNAs
modification. Increasing evidence illustrates its critical role on gastric cancer. Here, present …
modification. Increasing evidence illustrates its critical role on gastric cancer. Here, present …
[HTML][HTML] Downregulated METTL14 accumulates BPTF that reinforces super-enhancers and distal lung metastasis via glycolytic reprogramming in renal cell carcinoma
C Zhang, L Chen, Y Liu, J Huang, A Liu, Y Xu… - Theranostics, 2021 - ncbi.nlm.nih.gov
Background: Methyltransferase-like 14 (METTL14) participates in tumorigenesis in several
malignancies, but how METTL14 mediates the metastasis of renal cell carcinoma (RCC) has …
malignancies, but how METTL14 mediates the metastasis of renal cell carcinoma (RCC) has …
Paeonol inhibits the progression of intracerebral haemorrhage by mediating the HOTAIR/UPF1/ACSL4 axis
ZL Jin, WY Gao, SJ Liao, T Yu, Q Shi, SZ Yu… - ASN neuro, 2021 - journals.sagepub.com
Intracerebral haemorrhage (ICH) is a devastating subtype of stroke with high morbidity and
mortality. It has been reported that paeonol (PAN) inhibits the progression of ICH. However …
mortality. It has been reported that paeonol (PAN) inhibits the progression of ICH. However …
[HTML][HTML] The interplay between lncRNAs, RNA-binding proteins and viral genome during SARS-CoV-2 infection reveals strong connections with regulatory events …
Rationale: Viral infections are complex processes based on an intricate network of
molecular interactions. The infectious agent hijacks components of the cellular machinery for …
molecular interactions. The infectious agent hijacks components of the cellular machinery for …
LINC01021 maintains tumorigenicity by enhancing N6-methyladenosine reader IMP2 dependent stabilization of MSX1 and JARID2: implication in colorectal cancer
H Wu, X Ding, X Hu, Q Zhao, Q Chen, T Sun, Y Li… - Oncogene, 2022 - nature.com
Insulin-like growth factor-2 mRNA-binding protein 2 (IGF2BP2, also known as IMP2), a novel
class III N6-methyladenosine (m6A) reader, has recently gained attention due to its critical …
class III N6-methyladenosine (m6A) reader, has recently gained attention due to its critical …
Targeting the innate immune system with nanoparticles for cancer immunotherapy
K Li, Z Zhang, Y Mei, M Li, Q Yang, Q Wu… - Journal of Materials …, 2022 - pubs.rsc.org
Various cancer therapies have advanced remarkably over the past decade. Unlike the direct
therapeutic targeting of tumor cells, cancer immunotherapy is a new strategy that boosts the …
therapeutic targeting of tumor cells, cancer immunotherapy is a new strategy that boosts the …
LncRNA LINC01134 Contributes to Radioresistance in Hepatocellular Carcinoma by Regulating DNA Damage Response via MAPK Signaling Pathway
Z Wang, X Wang, Z Rong, L Dai, C Qin… - Frontiers in …, 2022 - frontiersin.org
Hepatocellular carcinoma (HCC) is a highly mortal cancer that could be treated by
radiotherapy. DNA damage response (DDR) is a vital factor affecting cancer development …
radiotherapy. DNA damage response (DDR) is a vital factor affecting cancer development …