Adaptive immune responses to primary and secondary dengue virus infections

AL St. John, APS Rathore - Nature Reviews Immunology, 2019 - nature.com
Dengue is the leading mosquito-borne viral illness infecting humans. Owing to the
circulation of multiple serotypes, global expansion of the disease and recent gains in …

Mathematical models for dengue fever epidemiology: A 10-year systematic review

M Aguiar, V Anam, KB Blyuss, CDS Estadilla… - Physics of Life …, 2022 - Elsevier
Mathematical models have a long history in epidemiological research, and as the COVID-19
pandemic progressed, research on mathematical modeling became imperative and very …

Antibody-dependent enhancement of severe dengue disease in humans

LC Katzelnick, L Gresh, ME Halloran, JC Mercado… - Science, 2017 - science.org
For dengue viruses 1 to 4 (DENV1-4), a specific range of antibody titer has been shown to
enhance viral replication in vitro and severe disease in animal models. Although suspected …

Dengue

G Paz-Bailey, LE Adams, J Deen, KB Anderson… - The Lancet, 2024 - thelancet.com
Dengue, caused by four closely related viruses, is a growing global public health concern,
with outbreaks capable of overwhelming health-care systems and disrupting economies …

Effects of boosting and waning in highly exposed populations on dengue epidemic dynamics

RA Aogo, JV Zambrana, N Sanchez, S Ojeda… - Science translational …, 2023 - science.org
Sequential infection with multiple dengue virus (DENV) serotypes is thought to induce
enduring protection against dengue disease. However, long-term antibody waning has been …

Intrinsic ADE: the dark side of antibody dependent enhancement during dengue infection

R Narayan, S Tripathi - Frontiers in cellular and infection microbiology, 2020 - frontiersin.org
Dengue fever is an Aedes mosquito-borne illness caused by any one of the four different
dengue virus (DENV) serotypes (1–4) and manifests in the form of symptoms ranging from …

Insights into dengue immunity from vaccine trials

EE Ooi, S Kalimuddin - Science translational medicine, 2023 - science.org
The quest for an effective dengue vaccine has culminated in two approved vaccines and
another that has completed phase 3 clinical trials. However, shortcomings exist in each …

Antigenic evolution of dengue viruses over 20 years

LC Katzelnick, A Coello Escoto, AT Huang… - Science, 2021 - science.org
Infection with one of dengue viruses 1 to 4 (DENV1-4) induces protective antibodies against
homotypic infection. However, a notable feature of dengue viruses is the ability to use …

Dengue: knowledge gaps, unmet needs, and research priorities

LC Katzelnick, J Coloma, E Harris - The Lancet Infectious Diseases, 2017 - thelancet.com
Dengue virus is a mosquito-borne pathogen that causes up to about 100 million cases of
disease each year, placing a major public health, social, and economic burden on …

Protection against symptomatic dengue infection by neutralizing antibodies varies by infection history and infecting serotype

S Bos, AL Graber, JA Cardona-Ospina… - Nature …, 2024 - nature.com
Abstract Dengue viruses (DENV1–4) are the most prevalent arboviruses in humans and a
major public health concern. Understanding immune mechanisms that modulate DENV …