Atherosclerosis is the main risk factor for cardiovascular disease (CVD), which is the leading
cause of mortality worldwide. Atherosclerosis is initiated by endothelium activation and …

Insulin is a polypeptide hormone mainly secreted by β cells in the islets of Langerhans of the
pancreas. The hormone potentially coordinates with glucagon to modulate blood glucose …

Cardiovascular diseases (CVD) are complex entities with heterogenous pathophysiologic
mechanisms and increased oxidative stress has been viewed as one of the potential …

Despite significant advances in the treatment of myocardial ischemia-reperfusion (I/R) injury,
coronary circulation is a so far neglected target of cardioprotection. In this study, we …

Ageing is associated with functional, structural and mechanical changes in arteries that
closely resemble the vascular alterations in hypertension. Characteristic features of large …

National space agencies and private corporations aim at an extended presence of humans
in space in the medium to long term. Together with currently suboptimal technology …

Aging can be seen as process characterized by accumulation of oxidative stress induced
damage. Oxidative stress derives from different endogenous and exogenous processes, all …

In mammalian cells, autophagy is the major pathway for the degradation and recycling of
obsolete and potentially noxious cytoplasmic materials, including proteins, lipids, and whole …

Inflammation, as a feature of rheumatoid arthritis (RA), leads to the activation of endothelial
cells (ECs). Activated ECs induce atherosclerosis through an increased expression of …

Acute vascular endothelial dysfunction is a central event in the pathogenesis of sepsis,
increasing vascular permeability, promoting activation of the coagulation cascade, tissue …