Puerarin attenuates the endothelial-mesenchymal transition induced by oxidative stress in human coronary artery endothelial cells through PI3K/AKT pathway

X Li, S Sun, D Chen, T Yuan, Y Chen, D Wang… - European Journal of …, 2020 - Elsevier
Endothelial-mesenchymal transition (EndMT) is a process in which endothelial cells lose
their specific morphology/markers and undergo a dramatic remodeling of the cytoskeleton. It …

[HTML][HTML] Crocin Improves Endothelial Mitochondrial Dysfunction via GPx1/ROS/KCa3.1 Signal Axis in Diabetes

X Li, Y Liu, A Cao, C Li, L Wang, Q Wu, X Li… - Frontiers in Cell and …, 2021 - frontiersin.org
Mitochondrial dysfunction contributes to excessive reactive oxygen species (ROS)
generation, which is a dramatic cause to promote endothelial dysfunction in diabetes. It was …

[HTML][HTML] TNF-α regulates the proteolytic degradation of ST6Gal-1 and endothelial cell-cell junctions through upregulating expression of BACE1

X Deng, J Zhang, Y Liu, L Chen, C Yu - Scientific reports, 2017 - nature.com
Endothelial dysfunction and monocyte adhesion to vascular endothelial cells are two critical
steps in atherosclerosis development, and emerging evidence suggests that protein …

[HTML][HTML] Effect of alpha-lipoic acid supplementation on endothelial function and cardiovascular risk factors in overweight/obese youths: a double-blind, placebo …

L Tromba, FM Perla, G Carbotta, C Chiesa, L Pacifico - Nutrients, 2019 - mdpi.com
Endothelial dysfunction is recognized as an early sign of systemic atherosclerosis, and it
represents a therapeutic target to prevent long-term cardiovascular (CV) consequences …

[HTML][HTML] Cardiovascular protection effect of chlorogenic acid: Focus on the molecular mechanism

M Lukitasari, MS Rohman, DA Nugroho… - …, 2020 - ncbi.nlm.nih.gov
Vascular endothelial cells have a variety of functions such as the control of blood
coagulation, vascular permeability, and tone regulation, as well as quiesce of immune cells …

[HTML][HTML] Chemical Characterization, Antioxidant Capacity and Anti-Oxidative Stress Potential of South American Fabaceae Desmodium tortuosum

JL Rodríguez, P Berrios, ZM Clavo, M Marin-Bravo… - Nutrients, 2023 - mdpi.com
It has been proposed that oxidative stress is a pathogenic mechanism to induce cytotoxicity
and to cause cardiovascular and neuronal diseases. At present, natural compounds such as …

Systematic review and meta‐analysis of the risk of severe and life‐threatening thromboembolism in cancer patients receiving anti‐EGFR monoclonal antibodies …

M Miroddi, C Sterrantino, M Simmonds… - … Journal of Cancer, 2016 - Wiley Online Library
Cancer‐associated thromboembolism is a substantial problem in clinical practice. An
increase in the level of fibrinopeptide A (a substance associated with hypercoagulable …

[HTML][HTML] Pycnogenol attenuates atherosclerosis by regulating lipid metabolism through the TLR4–NF-κB pathway

H Luo, J Wang, C Qiao, N Ma, D Liu… - Experimental & molecular …, 2015 - nature.com
Atherosclerosis is a leading cause of death worldwide and is characterized by lipid-laden
foam cell formation. Recently, pycnogenol (PYC) has drawn much attention because of its …

Recent advances in micro-and nano-bubbles for atherosclerosis applications

A Wijaya, A Maruf, W Wu, G Wang - Biomaterials Science, 2020 - pubs.rsc.org
Atherosclerosis is the most prevalent cause of cardiovascular disease-induced deaths
worldwide. Micro-and nano-bubbles (MNBs) have been developed as the vehicles for …

Didymin prevents hyperglycemia-induced human umbilical endothelial cells dysfunction and death

K Shukla, H Sonowal, A Saxena, KV Ramana - Biochemical pharmacology, 2018 - Elsevier
Although didymin, a flavonoid-O-glycosides compound naturally found in the citrus fruits,
has been reported to be a potent anticancer agent in the prevention of various cancers, its …