Oxidative stress in healthy and pathological red blood cells

F Orrico, S Laurance, AC Lopez, SD Lefevre… - Biomolecules, 2023 - mdpi.com
Red cell diseases encompass a group of inherited or acquired erythrocyte disorders that
affect the structure, function, or production of red blood cells (RBCs). These disorders can …

Moonlighting chromatin: when DNA escapes nuclear control

J Singh, M Boettcher, M Dölling, A Heuer… - Cell Death & …, 2023 - nature.com
Extracellular chromatin, for example in the form of neutrophil extracellular traps (NETs), is an
important element that propels the pathological progression of a plethora of diseases. DNA …

Production and characterization of bioactive peptides in fermented soybean meal produced using proteolytic Bacillus species isolated from kinema

R Kumari, N Sharma, S Sharma, S Samurailatpam… - Food Chemistry, 2023 - Elsevier
The study aims to enhance the functional properties of soybean meal (SBM) using potent
proteolytic Bacillus strains isolated from kinema, a traditional fermented soybean product of …

Rationale and design of ENDEAVOR: a sequential phase 2b–3 randomized clinical trial to evaluate the effect of myeloperoxidase inhibition on symptoms and exercise …

LH Lund, CSP Lam, PE Pizzato… - European Journal of …, 2023 - Wiley Online Library
Aims Mitiperstat (formerly AZD4831) is a novel selective myeloperoxidase inhibitor.
Currently, no effective therapies target comorbidity‐induced systemic inflammation, which …

N-acetylcysteine (NAC) and Its Role in Clinical Practice Management of Cystic Fibrosis (CF): A Review

M Guerini, G Condrò, V Friuli, L Maggi, P Perugini - Pharmaceuticals, 2022 - mdpi.com
N-acetylcysteine is the acetylated form of the amino acid L-cysteine and a precursor to
glutathione (GSH). It has been known for a long time as a powerful antioxidant and as an …

Destabilization of atherosclerotic plaque by bilirubin deficiency

W Chen, S Tumanov, CP Stanley, SMY Kong… - Circulation …, 2023 - Am Heart Assoc
Background: The rupture of atherosclerotic plaque contributes significantly to cardiovascular
disease. Plasma concentrations of bilirubin—a byproduct of heme catabolism—inversely …

Microbial metabolite regulation of epithelial cell-cell interactions and barrier function

A Ornelas, AS Dowdell, JS Lee, SP Colgan - Cells, 2022 - mdpi.com
Epithelial cells that line tissues such as the intestine serve as the primary barrier to the
outside world. Epithelia provide selective permeability in the presence of a large …

Antioxidant and Anti-Inflammatory Properties of Phytochemicals Found in the Yucca Genus

EB Culhuac, A Maggiolino, MMMY Elghandour… - Antioxidants, 2023 - mdpi.com
The Yucca genus encompasses about 50 species native to North America. Species within
the Yucca genus have been used in traditional medicine to treat pathologies related to …

Myeloperoxidase alters lung cancer cell function to benefit their survival

N Cosic-Mujkanovic, P Valadez-Cosmes, K Maitz… - Antioxidants, 2023 - mdpi.com
Myeloperoxidase (MPO) is a neutrophil-derived enzyme that has been recently associated
with tumour development. However, the mechanisms by which this enzyme exerts its …

Multimetallic transition metal complexes: Luminescent probes for biomolecule sensing, ion detection, imaging and therapeutic application

B Das, P Gupta - Coordination Chemistry Reviews, 2024 - Elsevier
In the past decade, luminescent multimetallic transition metal complexes have become
indispensable tools in biology. They enable versatile applications, detecting biomolecules …