Advanced imaging techniques for tracking drug dynamics at the subcellular level
Optical microscopes are an important imaging tool that have effectively advanced the
development of modern biomedicine. In recent years, super-resolution microscopy (SRM) …
development of modern biomedicine. In recent years, super-resolution microscopy (SRM) …
[HTML][HTML] Recent advances in the translation of drug metabolism and pharmacokinetics science for drug discovery and development
Y Lai, X Chu, L Di, W Gao, Y Guo, X Liu, C Lu… - … Pharmaceutica Sinica B, 2022 - Elsevier
Drug metabolism and pharmacokinetics (DMPK) is an important branch of pharmaceutical
sciences. The nature of ADME (absorption, distribution, metabolism, excretion) and PK …
sciences. The nature of ADME (absorption, distribution, metabolism, excretion) and PK …
OAT, OATP, and MRP drug transporters and the remote sensing and signaling theory
SK Nigam, JC Granados - Annual review of pharmacology and …, 2023 - annualreviews.org
The coordinated movement of organic anions (eg, drugs, metabolites, signaling molecules,
nutrients, antioxidants, gut microbiome products) between tissues and body fluids depends …
nutrients, antioxidants, gut microbiome products) between tissues and body fluids depends …
Pharmacokinetic and Pharmacodynamic Drug–Drug Interactions: Research Methods and Applications
L Sun, K Mi, Y Hou, T Hui, L Zhang, Y Tao, Z Liu… - Metabolites, 2023 - mdpi.com
Because of the high research and development cost of new drugs, the long development
process of new drugs, and the high failure rate at later stages, combining past drugs has …
process of new drugs, and the high failure rate at later stages, combining past drugs has …
From endogenous compounds as biomarkers to plasma‐derived nanovesicles as liquid biopsy; has the golden age of translational pharmacokinetics‐absorption …
D Rodrigues, A Rowland - Clinical Pharmacology & …, 2019 - Wiley Online Library
It is now established that a drug's pharmacokinetics (PK) absorption, distribution,
metabolism, excretion (ADME) and drug–drug interaction (DDI) profile can be modulated by …
metabolism, excretion (ADME) and drug–drug interaction (DDI) profile can be modulated by …
Evaluation of pharmacokinetic drug–drug interactions: a review of the mechanisms, in vitro and in silico approaches
Y Peng, Z Cheng, F Xie - Metabolites, 2021 - mdpi.com
Pharmacokinetic drug–drug interactions (DDIs) occur when a drug alters the absorption,
transport, distribution, metabolism or excretion of a co-administered agent. The occurrence …
transport, distribution, metabolism or excretion of a co-administered agent. The occurrence …
Quantitative contribution of six major transporters to the hepatic uptake of drugs:“SLC-phenotyping” using primary human hepatocytes
Y Bi, C Costales, S Mathialagan, M West… - … of Pharmacology and …, 2019 - ASPET
Hepatic uptake transporters [solute carriers (SLCs)], including organic anion transporting
polypeptide (OATP) 1B1, OATP1B3, OATP2B1, sodium-dependent taurocholate …
polypeptide (OATP) 1B1, OATP1B3, OATP2B1, sodium-dependent taurocholate …
Transporters in the mammary gland—contribution to presence of nutrients and drugs into milk
AM García-Lino, I Álvarez-Fernández… - Nutrients, 2019 - mdpi.com
A large number of nutrients and bioactive ingredients found in milk play an important role in
the nourishment of breast-fed infants and dairy consumers. Some of these ingredients …
the nourishment of breast-fed infants and dairy consumers. Some of these ingredients …
Imaging techniques to study drug transporter function in vivo
N Tournier, B Stieger, O Langer - Pharmacology & therapeutics, 2018 - Elsevier
Transporter systems involved in the permeation of drugs and solutes across biological
membranes are recognized as key determinants of pharmacokinetics. Typically, the action of …
membranes are recognized as key determinants of pharmacokinetics. Typically, the action of …
Current practices, gap analysis, and proposed workflows for PBPK modeling of cytochrome P450 induction: an industry perspective
N Hariparsad, D Ramsden, K Taskar… - Clinical …, 2022 - Wiley Online Library
The International Consortium for Innovation and Quality (IQ) Physiologically Based
Pharmacokinetic (PBPK) Modeling Induction Working Group (IWG) conducted a survey …
Pharmacokinetic (PBPK) Modeling Induction Working Group (IWG) conducted a survey …