NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential

N Xie, L Zhang, W Gao, C Huang, PE Huber… - Signal transduction and …, 2020 - nature.com
Nicotinamide adenine dinucleotide (NAD+) and its metabolites function as critical regulators
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …

NAFLD as a driver of chronic kidney disease

CD Byrne, G Targher - Journal of hepatology, 2020 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD) are worldwide
public health problems, affecting up to 25–30%(NAFLD), and up to 10–15%(CKD) of the …

Links between metabolic syndrome and metabolic dysfunction-associated fatty liver disease

S Lim, JW Kim, G Targher - Trends in Endocrinology & Metabolism, 2021 - cell.com
Metabolic dysfunction-associated fatty liver disease (MAFLD) is a chronic condition
characterized by hepatic fat accumulation combined with underlying metabolic …

CD36 favours fat sensing and transport to govern lipid metabolism

Y Li, X Huang, G Yang, K Xu, Y Yin, G Brecchia… - Progress in lipid …, 2022 - Elsevier
CD36, located on the cell membrane, transports fatty acids in response to dietary fat. It is a
critical fatty acid sensor and regulator of lipid metabolism. The interaction between CD36 …

Targeting autophagy in obesity: from pathophysiology to management

Y Zhang, JR Sowers, J Ren - Nature Reviews Endocrinology, 2018 - nature.com
Obesity poses a severe threat to human health, including the increased prevalence of
hypertension, insulin resistance, diabetes mellitus, cancer, inflammation, sleep apnoea and …

[HTML][HTML] Invited review liver fibrosis in NAFLD/NASH: From pathophysiology towards diagnostic and therapeutic strategies

M Parola, M Pinzani - Molecular Aspects of Medicine, 2024 - Elsevier
Liver fibrosis, as an excess deposition of extracellular matrix (ECM) components, results
from chronic liver injury as well as persistent activation of inflammatory response and of …

The complex interplay between mitochondria, ROS and entire cellular metabolism

AV Kuznetsov, R Margreiter, MJ Ausserlechner… - Antioxidants, 2022 - mdpi.com
Besides their main function for energy production in form of ATP in processes of oxidative
phosphorylation (OxPhos), mitochondria perform many other important cellular functions …

Advances in the diagnosis and treatment of non-alcoholic fatty liver disease

X Yin, X Guo, Z Liu, J Wang - International Journal of Molecular Sciences, 2023 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease that
affects approximately one-quarter of the global adult population, posing a significant threat …

Protective Effects of (E)-β-Caryophyllene (BCP) in Chronic Inflammation

R Scandiffio, F Geddo, E Cottone, G Querio… - Nutrients, 2020 - mdpi.com
(E)-β-caryophyllene (BCP) is a bicyclic sesquiterpene widely distributed in the plant
kingdom, where it contributes a unique aroma to essential oils and has a pivotal role in the …

Oxidative stress and reproductive function: oxidative stress in polycystic ovary syndrome

E Rudnicka, AM Duszewska, M Kucharski… - …, 2022 - rep.bioscientifica.com
In brief A genetic, epigenetic, and environmental association exists between oxidative stress
(OS) and polycystic ovary syndrome (PCOS), expressed in a multifaceted clinical profile …