Myocardial ischemia is a disease with high morbidity and mortality, for which reperfusion is
currently the standard intervention. However, the reperfusion may lead to further myocardial …

Ischemia-reperfusion (IR) injury is central to the pathology of major cardiovascular diseases,
such as stroke and myocardial infarction. IR injury is mediated by several factors including …

Mitochondria are the key source of ATP that fuels cellular functions, and they are also central
in cellular signaling, cell division and apoptosis. Dysfunction of mitochondria has been …

The mitochondrial permeability transition pore (MPTP) is a non-specific pore that opens in
the inner mitochondrial membrane (IMM) when matrix [Ca 2+] is high, especially when …

Doxorubicin (DOX) is an anticancer anthracycline that presents a dose‐dependent and
cumulative cardiotoxicity as one of the most serious side effects. Several hypotheses have …

A variety of stimuli utilize an increase of cytosolic free Ca2+ concentration as a second
messenger to transmit signals, through Ca2+ release from the endoplasmic reticulum or …

Mitochondria play a critical role in maintaining cellular function by ATP production. They are
also a source of reactive oxygen species (ROS) and proapoptotic factors. The role of …

The field of mitochondrial ion channels has recently seen substantial progress, including the
molecular identification of some of the channels. An integrative approach using genetics …

Cardiac failure is a leading cause of age-related death, though its root cause remains
unknown. Mounting evidence implicates a decline in mitochondrial function due to …

Extracellular vesicles (EVs) derived from various stem cell sources induce cardioprotective
effects during ischemia-reperfusion injury (IRI). These have been attributed mainly to the …