The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …

CaMKII (the multifunctional Ca2+ and calmodulin-dependent protein kinase II) is a highly
validated signal for promoting a variety of common diseases, particularly in the …

Gallic acid (GA) has been reported to have beneficial effects on cancer, vascular
calcification, and diabetes-induced myocardial dysfunction. We hypothesized that GA …

Abstract Background Prostate cancer (PCa) is the most frequently diagnosed malignancy in
men, and its mechanism remains poorly understood. Therefore, it is urgent to discover …

CaMKII is activated by oxidation of methionine residues residing in the regulatory domain.
Oxidized CaMKII (ox-CaMKII) is now thought to participate in cardiovascular and pulmonary …

Calcium/calmodulin-dependent protein kinases (CaMKs) are key regulators of calcium
signaling in health and disease. CaMKII is the most abundant isoform in the heart; although …

Hypertensive vascular remodeling is defined as the changes in vascular function and
structure induced by persistent hypertension. Maresin‐1 (MaR1), one of metabolites from …

LncRNAs represent a large class of noncoding RNA molecules that have important functions
and play key roles in a variety of human diseases. There is an urgent need to develop …

Background Sex‐specific differences in vasodilation are mediated in part by differences in
cytosolic Ca2+ handling, but how variations in mitochondrial Ca2+ contributes to this effect …

Background Hypertension, clinically defined by elevated blood pressure (BP), is an
important cause of mortality and morbidity worldwide. Many risk factors for hypertension are …