Background Post-translational modification is considered an important biological
mechanism with critical impact on the diversification of the proteome. Although a long list of …

Abstract Post-Translational Modification (PTM) is a biological reaction which contributes to
diversify the proteome. Despite many modifications with important roles in cellular activity …

Covalent drug discovery has undergone a resurgence over the past two decades and
reactive cysteine profiling has emerged in parallel as a platform for ligand discovery through …

The transcription co-activator complex SAGA is recruited to gene promoters by sequence-
specific transcriptional activators and by chromatin modifications to promote pre-initiation …

The biological process known as post-translational modification (PTM) contributes to
diversifying the proteome hence affecting many aspects of normal cell biology and …

Carbohydrate-binding proteins play vital roles in many important biological processes. The
study of these protein-carbohydrate interactions, at residue level, is useful in treating many …

We initially extracted 13 datasets from different experiments among six species: human,
mouse, zebrafish, Drosophila, Ciona intestinalis, and C. elegans (Supplementary Table 1) …

Accurately predicting the impact of point mutation on protein stability has crucial roles in
protein design and engineering. In this study, we proposed a novel method (BoostDDG) to …

Malonylation is a recently discovered post‐translational modification (PTM) in which a
malonyl group attaches to a lysine (K) amino acid residue of a protein. In this work, a novel …

Glycation is chemical reaction by which sugar molecule bonds with a protein without the
help of enzymes. This is often cause to many diseases and therefore the knowledge about …