Background: Protein S-Sulfenylation, the reversible oxidative modification of cysteine thiol
groups to cysteine S-Sulfenic acids, is a post-translational modification (PTM) that plays a …

Covalent drug discovery, in particular targeting reactive cysteines, has undergone a
resurgence over the past two decades, demonstrated by recent clinical successes of …

Intrinsically disordered proteins (IDPs) represent a distinct class of proteins and are
distinguished from globular proteins by conformational plasticity, high evolvability and a …

It has been long established that cis conformations of amino acid residues play many
biologically important roles despite their rare occurrence in protein structure. Because of this …

Abstract Predicting the three-dimensional (3-D) structure of a protein is an important task in
the field of bioinformatics and biological sciences. However, directly predicting the 3-D …

Methylation is considered one of the proteins' most important post-translational modifications
(PTM). Plasticity and cellular dynamics are among the many traits that are regulated by …

Background Protein structure can be described by backbone torsion angles: rotational
angles about the N-Cα bond (φ) and the Cα-C bond (ψ) or the angle between Cα i-1-Cα i-Cα …

Background: Prediction of proteins' secondary structure is one of the major steps in the
generation of homology models. These models provide structural information which is used …

The prominence of protein–protein interactions (PPIs) in system biology with diverse
biological procedures has become the topic to discuss because it acts as a fundamental part …

Seasonal influenza viruses undergo frequent mutations on their surface hemagglutinin (HA)
proteins to escape the host immune response. In these mutations, a few key amino acid sites …