Immunological memory to SARS‐CoV‐2 infection and COVID‐19 vaccines

A Sette, S Crotty - Immunological reviews, 2022 - Wiley Online Library
Immunological memory is the basis of protective immunity provided by vaccines and
previous infections. Immunological memory can develop from multiple branches of the …

SARS-CoV-2 omicron variant: epidemiological features, biological characteristics, and clinical significance

Y Guo, J Han, Y Zhang, J He, W Yu, X Zhang… - Frontiers in …, 2022 - frontiersin.org
The SARS-CoV-2 Omicron (B. 1.1529) variant was designated as a variant of concern (VOC)
by the World Health Organization (WHO) on November 26, 2021. Within two months, it had …

Immune boosting by B. 1.1. 529 (Omicron) depends on previous SARS-CoV-2 exposure

CJ Reynolds, C Pade, JM Gibbons, AD Otter, KM Lin… - Science, 2022 - science.org
The Omicron, or Pango lineage B. 1.1. 529, variant of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) carries multiple spike mutations with high transmissibility and …

Imprinted antibody responses against SARS-CoV-2 Omicron sublineages

YJ Park, D Pinto, AC Walls, Z Liu, A De Marco… - Science, 2022 - science.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron sublineages carry
distinct spike mutations resulting in escape from antibodies induced by previous infection or …

Omicron spike function and neutralizing activity elicited by a comprehensive panel of vaccines

JE Bowen, A Addetia, HV Dang, C Stewart, JT Brown… - Science, 2022 - science.org
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of
concern comprises several sublineages, with BA. 2 and BA. 2.12. 1 having replaced the …

Omicron BA. 4/BA. 5 escape neutralizing immunity elicited by BA. 1 infection

K Khan, F Karim, Y Ganga, M Bernstein, Z Jule… - Nature …, 2022 - nature.com
Abstract SARS-CoV-2 Omicron (B. 1.1. 529) BA. 4 and BA. 5 sub-lineages, first detected in
South Africa, have changes relative to Omicron BA. 1 including substitutions in the spike …

mRNA-1273 or mRNA-Omicron boost in vaccinated macaques elicits similar B cell expansion, neutralizing responses, and protection from Omicron

M Gagne, JI Moliva, KE Foulds, SF Andrew, BJ Flynn… - Cell, 2022 - cell.com
SARS-CoV-2 Omicron is highly transmissible and has substantial resistance to
neutralization following immunization with ancestral spike-matched vaccines. It is unclear …

Fc-γR-dependent antibody effector functions are required for vaccine-mediated protection against antigen-shifted variants of SARS-CoV-2

SR Mackin, P Desai, BM Whitener, CE Karl, M Liu… - Nature …, 2023 - nature.com
Emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with
antigenic changes in the spike protein are neutralized less efficiently by serum antibodies …

Recall of preexisting cross-reactive B cell memory after Omicron BA. 1 breakthrough infection

CI Kaku, AJ Bergeron, C Ahlm, J Normark… - Science …, 2022 - science.org
Understanding immune responses after severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) breakthrough infection will facilitate the development of next-generation …

Omicron infection enhances Delta antibody immunity in vaccinated persons

K Khan, F Karim, S Cele, K Reedoy, JE San, G Lustig… - Nature, 2022 - nature.com
The extent to which Omicron infection,,,,,,,–, with or without previous vaccination, elicits
protection against the previously dominant Delta (B. 1.617. 2) variant is unclear. Here we …