Pre-eclampsia

LC Chappell, CA Cluver, S Tong - The Lancet, 2021 - thelancet.com
Pre-eclampsia is a multisystem pregnancy disorder characterised by variable degrees of
placental malperfusion, with release of soluble factors into the circulation. These factors …

Preeclampsia: pathophysiology, challenges, and perspectives

S Rana, E Lemoine, JP Granger… - Circulation …, 2019 - Am Heart Assoc
Hypertensive disorders of pregnancy—chronic hypertension, gestational hypertension, and
preeclampsia—are uniquely challenging as the pathology and its therapeutic management …

Pre-eclampsia: pathogenesis, novel diagnostics and therapies

EA Phipps, R Thadhani, T Benzing… - Nature Reviews …, 2019 - nature.com
Pre-eclampsia is a complication of pregnancy that is associated with substantial maternal
and fetal morbidity and mortality. The disease presents with new-onset hypertension and …

[HTML][HTML] Failure of physiological transformation and spiral artery atherosis: their roles in preeclampsia

AC Staff, HE Fjeldstad, IK Fosheim, K Moe… - American journal of …, 2022 - Elsevier
Physiological transformation with remodeling of the uteroplacental spiral arteries is key to a
successful placentation and normal placental function. It is an intricate process that involves …

Antiphospholipid syndrome

K Schreiber, S Sciascia, PG De Groot… - Nature reviews Disease …, 2018 - nature.com
Antiphospholipid syndrome (APS) is an autoimmune disease characterized by the presence
of antiphospholipid antibodies, such as lupus anticoagulant, anticardiolipin antibodies and …

The role of immune cells and mediators in preeclampsia

E Deer, O Herrock, N Campbell, D Cornelius… - Nature Reviews …, 2023 - nature.com
Preeclampsia is a hypertensive disorder of major concern in pregnancy than can lead to
intrauterine growth restriction, placental abruption and stillbirth. The pathophysiology of …

[HTML][HTML] Oxidative stress in placental pathology

MH Schoots, SJ Gordijn, SA Scherjon, H van Goor… - Placenta, 2018 - Elsevier
The most important function of the placenta is the exchange of nutrients and oxygen
between a mother and her fetus. To establish a healthy functioning placenta, placentation …

Pravastatin versus placebo in pregnancies at high risk of term preeclampsia

M Döbert, AN Varouxaki, AC Mu, A Syngelaki… - Circulation, 2021 - Am Heart Assoc
Background: Effective screening for term preeclampsia is provided by a combination of
maternal factors with measurements of mean arterial pressure, serum placental growth …

Immunomodulatory effects of vitamin D in pregnancy and beyond

F Cyprian, E Lefkou, K Varoudi, G Girardi - Frontiers in immunology, 2019 - frontiersin.org
In addition to its role in calcium homeostasis and bone formation, a modulatory role of the
active form of vitamin D on cells of the immune system, particularly T lymphocytes, has been …

Antiphospholipid syndrome

LR Sammaritano - Best Practice & Research Clinical Rheumatology, 2020 - Elsevier
Antiphospholipid syndrome is an autoimmune systemic disorder characterized by arterial,
venous, or small vessel thrombosis and/or recurrent early pregnancy loss, fetal loss, or …