Therapeutic role of neutralizing antibody for the treatment against SARS-CoV-2 and its emerging variants: A clinical and pre-clinical perspective

M Bhattacharya, S Chatterjee, B Mallik, AR Sharma… - Vaccines, 2022 - mdpi.com
Since early 2020, the entire world has been facing a disastrous outbreak of the SARS-CoV-2
virus, with massive reporting of death and infections per day. Medical practitioners adopted …

Potential COVID‐19 therapeutic approaches targeting angiotensin‐converting enzyme 2; an updated review

S Zanganeh, N Goodarzi, M Doroudian… - Reviews in Medical …, 2022 - Wiley Online Library
COVID‐19 has spread swiftly throughout the world posing a global health emergency. The
significant numbers of deaths attributed to this pandemic have researchers battling to …

From concept to delivery: a yeast-expressed recombinant protein-based COVID-19 vaccine technology suitable for global access

PJ Hotez, R Adhikari, WH Chen, YL Chen… - Expert Review of …, 2023 - Taylor & Francis
Introduction The development of a yeast-expressed recombinant protein-based vaccine
technology co-developed with LMIC vaccine producers and suitable as a COVID-19 vaccine …

The rapid adaptation of SARS-CoV-2–rise of the variants: transmission and resistance

SM Soh, Y Kim, C Kim, US Jang, HR Lee - Journal of Microbiology, 2021 - Springer
The causative factor of COVID-19, severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) is continuously mutating. Interestingly, identified mutations mainly occur in the spike …

A comprehensive review on immunogen and immune-response proteins of SARS-CoV-2 and their applications in prevention, diagnosis, and treatment of COVID-19

D Zhang, D Kukkar, KH Kim, P Bhatt - International Journal of Biological …, 2024 - Elsevier
Exposure to severe acute respiratory syndrome-corona virus-2 (SARS-CoV-2) prompts
humoral immune responses in the human body. As the auxiliary diagnosis of a current …

Exposure of progressive immune dysfunction by SARS-CoV-2 mRNA vaccination in patients with chronic lymphocytic leukemia: A prospective cohort study

K Qin, K Honjo, S Sherrill-Mix, W Liu, RM Stoltz… - PLoS …, 2023 - journals.plos.org
Background Patients with chronic lymphocytic leukemia (CLL) have reduced seroconversion
rates and lower binding antibody (Ab) and neutralizing antibody (NAb) titers than healthy …

[HTML][HTML] COVID-19 vaccine decisions: considering the choices and opportunities

PJ Hotez, T Nuzhath, T Callaghan, B Colwell - Microbes and Infection, 2021 - Elsevier
In the coming months, most American adults will have the opportunity to receive at least one
of up to five different COVID-19 vaccines produced by Operation Warp Speed and released …

A urinary proteomic landscape of COVID-19 progression identifies signaling pathways and therapeutic options

Y Liu, L Song, N Zheng, J Shi, H Wu, X Yang… - Science China Life …, 2022 - Springer
Signaling pathway alterations in COVID-19 of living humans as well as therapeutic targets of
the host proteins are not clear. We analyzed 317 urine proteomes, including 86 COVID-19 …

Integrative proteomics identifies thousands of distinct, multi-epitope, and high-affinity nanobodies

Y Xiang, Z Sang, L Bitton, J Xu, Y Liu… - Cell systems, 2021 - cell.com
The antibody immune response is essential for the survival of mammals. However, we still
lack a systematic understanding of the antibody repertoire. Here, we developed a proteomic …

A highly potent SARS-CoV-2 blocking lectin protein

RE Ahan, A Hanifehnezhad, ES Kehribar… - ACS Infectious …, 2022 - ACS Publications
The COVID-19 (coronavirus disease-19) pandemic affected more than 180 million people
around the globe, causing more than five million deaths as of January 2022. SARS-CoV-2 …