[PDF][PDF] Integrative proteomics identifies thousands of distinct, multi-epitope, and high-affinity nanobodies

Y Xiang, Z Sang, L Bitton, J Xu, Y Liu… - Cell systems, 2021 - cell.com
The antibody immune response is essential for the survival of mammals. However, we still
lack a systematic understanding of the antibody repertoire. Here, we developed a proteomic …

A highly potent SARS-CoV-2 blocking lectin protein

RE Ahan, A Hanifehnezhad, ES Kehribar… - ACS Infectious …, 2022 - ACS Publications
The COVID-19 (coronavirus disease-19) pandemic affected more than 180 million people
around the globe, causing more than five million deaths as of January 2022. SARS-CoV-2 …

Upregulation of the renin–angiotensin system pathways and SARS-CoV-2 infection: the rationale for the administration of zinc-chelating agents in COVID-19 patients

L Zamai - Cells, 2021 - mdpi.com
The article describes the rationale for the administration of zinc-chelating agents in COVID-
19 patients. In a previous work I have highlighted that the binding of the SARS-CoV spike …

L‐Glycosidase‐Cleavable Natural Glycans Facilitate the Chemical Synthesis of Correctly Folded Disulfide‐Bonded D‐Proteins

W Shi, T Wang, Z Yang, Y Ren, D Han… - Angewandte …, 2024 - Wiley Online Library
D‐peptide ligands can be screened for therapeutic potency and enzymatic stability using
synthetic mirror‐image proteins (D‐proteins), but efficient acquisition of these D‐proteins …

Review of therapeutic mechanisms and applications based on SARS-CoV-2 neutralizing antibodies

M Liu, H Gan, Z Liang, L Liu, Q Liu, Y Mai… - Frontiers in …, 2023 - frontiersin.org
COVID-19 pandemic is a global public health emergency. Despite extensive research, there
are still few effective treatment options available today. Neutralizing-antibody-based …

A comprehensive review on immunogen and immune-response proteins of SARS-CoV-2 and their applications in prevention, diagnosis, and treatment of COVID-19

D Zhang, D Kukkar, KH Kim, P Bhatt - International Journal of Biological …, 2024 - Elsevier
Exposure to severe acute respiratory syndrome-corona virus-2 (SARS-CoV-2) prompts
humoral immune responses in the human body. As the auxiliary diagnosis of a current …

COVID-19 patient serum less potently inhibits ACE2-RBD binding for various SARS-CoV-2 RBD mutants

D Junker, A Dulovic, M Becker, TR Wagner… - Scientific Reports, 2022 - nature.com
As global vaccination campaigns against SARS-CoV-2 proceed, there is particular interest
in the longevity of immune protection, especially with regard to increasingly infectious virus …

[HTML][HTML] Molecular perspectives of SARS-CoV-2: pathology, immune evasion, and therapeutic interventions

M Shah, HG Woo - Molecules and Cells, 2021 - Elsevier
The outbreak of coronavirus disease 2019 (COVID-19) has not only affected human health
but also diverted the focus of research and derailed the world economy over the past year …

Nanobodies as powerful pulmonary targeted biotherapeutics against SARS-CoV-2, pharmaceutical point of view

A Najmeddin, MB Shapourabadi, M Behdani… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Abstract Background Since December 2019, the newly emerged SARS-CoV-2 virus
continues to infect humans and many people died from severe Covid-19 during the last 2 …

[HTML][HTML] Exploring the future of SARS-CoV-2 treatment after the first two years of the pandemic: A comparative study of alternative therapeutics

B Babalola, OS Akinsuyi, EM Folajimi, F Olujimi… - Biomedicine & …, 2023 - Elsevier
One of the most pressing challenges associated with SARS-CoV-2 treatment is the
emergence of new variants that may be more transmissible, cause more severe disease, or …